SPECIALIZED MATERIALS SCIENCE RESEARCH CENTER

汞合金的替代品应满足以下主要要求： 生物相容性，牙体结构保护，牙体粘附 结构、处理不灵敏、修复缺陷或缺失 牙齿结构，美观，耐用，高寿命成本比 比例 由于已知的技术敏感性的替代 目前使用的修复材料， 报告的临床性能，拟议的研究将集中在 开发一种修复系统， 设计用于最小化技术敏感性的结构。 在 此外，我们的研究将集中在补充材料， 增强粘合剂/修复材料系统的粘附性， 牙本质，并将确保上级临床性能相比， 汞合金 该中心提案的总体目标是制定一项 完整的修复材料系统，包括牙本质调理剂， 牙本质粘结剂、树脂基复合物、树脂粘固剂和 用于镶嵌和牙冠的陶瓷。 拟议的系统将被设计为 1)在去矿物质条件下（pH值在4.0和5.5之间）释放， 脱矿指示剂，例如9-氨基吖啶，氟化物， 来自聚合物的矿化剂和细菌控制剂 微球，2）通过调理剂/底漆有效调理牙本质 由氨基改性的聚丙烯酸组成， 粘合剂与脱矿物质胶原纤维的相容性， 3)确保粘合剂之间有效的水解稳定的粘合 试剂和牙釉质，调理牙本质，牙骨质，树脂基复合材料， 和陶瓷，4）在聚合过程中导致最小的收缩， 通过选择性共混反应性单体的新型树脂基复合材料 和通过催化水解膨胀的溶胶-凝胶衍生的玻璃，5） 在玻璃陶瓷表面上提供不透水涂层， 基于氧化铝的防腐剂，和6）恢复腐烂的，损坏的，或 牙齿变色美观，牙齿减少最小 使用玻璃陶瓷和氧化铝基氧化铝芯陶瓷的结构， 0.5至1.3 mm的减小的厚度。 本材料开发计划将采用以下方法：1）在- 从微球化聚合物微球的需求控制释放 在特定pH值水平控制的速率下，2）优化 牙本质调理剂和粘合剂，以增强 胶原网络内的牙本质粘合剂，3）溶胶-凝胶的使用 和摩擦化学保护表面涂层，增韧陶瓷（链- 二氧化硅和钡云母玻璃陶瓷）和高模量树脂水泥 尽量减少假体过早断裂的风险， 敏感性，和4）控制复合材料聚合收缩， 水解控制的基质溶胀。 基于成功的 完成生物相容性试验，1年临床可行性 第五年将进行有前途的产品的试验。 这些 这项研究将得到佛罗里达大学的部分支持。 这 一个为期五年的中心计划，包括四个项目， 管理/统计核心和生物/临床核心将 由一个多学科团队组成，其主要目标是开发 耐用，技术不敏感的修复材料， 汞合金

Alternatives to amalgam should satisfy the primary requirements of biocompatibility, conservation of tooth structure, adhesion to tooth structure, handling insensitivity, restoration of defective or missing tooth structure, good esthetics, durability, and a high lifetime-to-cost ratio. Because of the known technique sensitivity of alternative restorative materials in use today as demonstrated by the variability in reported clinical performance, the proposed research will focus on the development of a restorative system with an integrated engineered structure that is designed to minimize technique sensitivity. In addition, our research will focus on complementary materials that will enhance adhesion of the bonding agent/restorative material system to dentin, and that will ensure superior clinical performance compared with amalgam. The overall objective of this Center proposal is to develop a complete restorative material system, consisting of a dentin conditioner, dentin-bonding agent, a resin-based composite, resin cement, and a ceramic for inlays and crowns. The proposed system will be designed to 1) release, under demineralizing conditions (pH between 4.0 and 5.5), demineralization indicators, such as 9-aminoacridine, fluoride, remineralizing agents, and bacteria-controlling agents from polymer microspheres, 2) condition dentin effectively via a conditioner/primer consisting of polyacrylic acid modified with amino groups for enhanced compatibility of the bonding agent with demineralized collagen fibers, 3) ensure an effective, hydrolytically stable bond between the bonding agent and enamel, conditioned dentin, cementum, resin-based composites, and ceramics, 4) result in minimal shrinkage during polymerization of novel resin-based composites via selective blending of reactive monomers and sol-gel derived glasses that expand by catalytic hydrolysis, 5) provide water-impermeable coatings on surfaces of glass-ceramic and alumina-based restorations, and 6) restore decayed, damaged, or discolored teeth esthetically and with minimal reduction of tooth structure using glass-ceramic and alumina-based alumina-core ceramic with a reduced thickness of 0.5 to 1.3 mm. Four novel technological approaches will be employed in this material development program: 1) on- demand controlled release from polymer microspheres of remineralization agents at rates controlled by specific pH levels, 2) the optimization of dentin conditioning and bonding agents to enhance the penetration of dentin bonding agents within a collagen network, 3) the use of sol-gel and tribochemical protective surface coatings, toughened ceramics (chain- silica and barium-mica glass-ceramics), and high-modulus resin cements to minimize the risk of premature prosthesis fracture and technique sensitivity, and 4) the control of composite polymerization shrinkage by hydrolysis-controlled matrix swelling . Based on the successful completion of biocompatibility tests, one-year clinical feasibility trials of promising products will be conducted in the fifth year. These studies will be supported in part by the University of Florida. This five-year Center program, consisting of four projects, an Administrative/Statistical core, and a Biological/Clinical Core, will be staffed by a multidisciplinary team whose main objective is to develop durable, technique insensitive restorative materials as alternatives to amalgam.