SPECIALIZED MATERIALS SCIENCE RESEARCH CENTER

汞齐的替代品应满足以下主要要求 生物相容性，保存牙齿结构，与牙齿粘连 结构、处理不敏感、修复有缺陷或丢失 牙齿结构、良好的美观性、耐用性和高寿命/成本 比率由于已知的技术敏感性，替代方案 当今使用的修复材料，如 报告的临床表现，建议的研究将集中在 一种具有集成工程的恢复性系统的开发 旨在最大限度地减少技术敏感性的结构。在……里面 此外，我们的研究将专注于补充材料， 增强粘结剂/修复材料系统的粘附性 牙本质，这将确保与 汞合金。该中心提案的总体目标是开发一种 完整的修复材料系统，由牙本质护发素组成， 牙本质粘结剂、树脂基复合材料、树脂粘固剂和 用于镶嵌和牙冠的陶瓷。拟议的系统将被设计为 1)在除盐条件下(pH值在4.0-5.5之间)释放， 脱矿指示剂，如9-氨基吖啶、氟化物、 聚合物中的再矿化剂和抑菌剂 微球，2)通过护发素/引发剂有效地调节牙本质 由氨基修饰的聚丙烯酸组成，用于增强 粘合剂与脱矿胶原纤维的相容性， 3)确保粘合之间的有效、水解性稳定的粘合 试剂和牙釉质，有条件牙本质，牙骨质，树脂基复合材料， 和陶瓷，4)在聚合过程中使收缩最小 反应性单体选择性共混制备新型树脂基复合材料 以及通过催化水解法膨胀的溶胶-凝胶衍生玻璃，5) 在微晶玻璃和玻璃表面提供防水涂层 氧化铝修复，以及6)修复腐烂、损坏或 美观的变色牙齿和最小的牙齿减少 采用微晶玻璃和氧化铝基氧化铝核陶瓷的结构 减薄后的厚度为0.5至1.3毫米。四大新技术 该材料开发计划将采用以下方法：1)关于- 再矿化聚合物微球的需求控制释放 由特定pH水平控制的速度的试剂，2)优化 牙本质调理剂和粘结剂增强牙本质的渗透性 胶原网内牙本质粘结剂，3)溶胶-凝胶的使用 和摩擦化学防护表面涂层、增韧陶瓷(链- 二氧化硅和钡-云母微晶玻璃)和高模树脂水泥 最大限度地减少假体过早骨折的风险和技术 敏感性，以及4)复合聚合收缩的控制 可控的水解性基质膨胀。基于成功的 完成生物相容性测试，一年临床可行性 有前景的产品将在第五年进行试验。这些 研究将得到佛罗里达大学的部分支持。这 五年中心方案，由四个项目组成，一个 行政/统计核心和生物/临床核心将是 由一个多学科团队组成，其主要目标是开发 耐用、技术不敏感的修复材料作为替代材料 汞合金。

Alternatives to amalgam should satisfy the primary requirements of biocompatibility, conservation of tooth structure, adhesion to tooth structure, handling insensitivity, restoration of defective or missing tooth structure, good esthetics, durability, and a high lifetime-to-cost ratio. Because of the known technique sensitivity of alternative restorative materials in use today as demonstrated by the variability in reported clinical performance, the proposed research will focus on the development of a restorative system with an integrated engineered structure that is designed to minimize technique sensitivity. In addition, our research will focus on complementary materials that will enhance adhesion of the bonding agent/restorative material system to dentin, and that will ensure superior clinical performance compared with amalgam. The overall objective of this Center proposal is to develop a complete restorative material system, consisting of a dentin conditioner, dentin-bonding agent, a resin-based composite, resin cement, and a ceramic for inlays and crowns. The proposed system will be designed to 1) release, under demineralizing conditions (pH between 4.0 and 5.5), demineralization indicators, such as 9-aminoacridine, fluoride, remineralizing agents, and bacteria-controlling agents from polymer microspheres, 2) condition dentin effectively via a conditioner/primer consisting of polyacrylic acid modified with amino groups for enhanced compatibility of the bonding agent with demineralized collagen fibers, 3) ensure an effective, hydrolytically stable bond between the bonding agent and enamel, conditioned dentin, cementum, resin-based composites, and ceramics, 4) result in minimal shrinkage during polymerization of novel resin-based composites via selective blending of reactive monomers and sol-gel derived glasses that expand by catalytic hydrolysis, 5) provide water-impermeable coatings on surfaces of glass-ceramic and alumina-based restorations, and 6) restore decayed, damaged, or discolored teeth esthetically and with minimal reduction of tooth structure using glass-ceramic and alumina-based alumina-core ceramic with a reduced thickness of 0.5 to 1.3 mm. Four novel technological approaches will be employed in this material development program: 1) on- demand controlled release from polymer microspheres of remineralization agents at rates controlled by specific pH levels, 2) the optimization of dentin conditioning and bonding agents to enhance the penetration of dentin bonding agents within a collagen network, 3) the use of sol-gel and tribochemical protective surface coatings, toughened ceramics (chain- silica and barium-mica glass-ceramics), and high-modulus resin cements to minimize the risk of premature prosthesis fracture and technique sensitivity, and 4) the control of composite polymerization shrinkage by hydrolysis-controlled matrix swelling . Based on the successful completion of biocompatibility tests, one-year clinical feasibility trials of promising products will be conducted in the fifth year. These studies will be supported in part by the University of Florida. This five-year Center program, consisting of four projects, an Administrative/Statistical core, and a Biological/Clinical Core, will be staffed by a multidisciplinary team whose main objective is to develop durable, technique insensitive restorative materials as alternatives to amalgam.