CENTER FOR DIGESTIVE AND LIVER DISEASES

这份修订后的消化系统疾病研究中心核心提案将统一 多学科联动侦查工作再上新台阶 融合消化生物学、病理生物学和治疗。这个 科学的焦点是细胞生长的分子控制和 消化器官分化及其相互关系的探讨 炎症性和肿瘤性疾病的过程。研究的基础是 通过讨论、试剂交流和 调查人员之间的科学合作。数量 调查人员从最初提议的35人减少到26人 希望进一步发展互动式研究小组的科学家。 在科学焦点中，一些主题已经演变成哪些联系 中心的研究人员在一起，包括基因调控，炎症 以及免疫学、细胞生长调控和肿瘤生物学。四 开发科学核心的目标是提供 特定于消化的服务和试剂以及刺激协作 研究。核心内容包括形态学、分子生物学、转基因 还有嵌合体老鼠和矢量。管理核心将由以下人员领导 主任彼得·G·特拉伯和科学/副主任， 丽贝卡·A·特劳布。这一核心将指导财务和组织 该中心的方方面面，包括制定浓缩方案 和电子通信。选定了试点项目/可行性项目 基于它们与科学焦点和优先事项的相关性 在年轻研究人员中促进消化研究。这些建议 包括：1)Alagille致病基因的定位克隆 综合征，2)肠道发育中的PRL-1，3)诱导和 非洲爪哇内胚层谱系的图案化和4)反应 综合症。除了这些建议的首席调查员外， 有一支优秀的年轻调查员队伍将受益于 来自宾夕法尼亚大学消化系统疾病中心。在……里面 综上所述，这项修订后的提案提供的证据表明， 两年前提出的中心已经成熟并发展成为一个实体 在大学科学界内。伊利诺伊大学 宾夕法尼亚州准备利用资金为 消化系统疾病研究核心中心。

This revised Digestive Diseases Research Core Center proposal will unite investigators from multiple discipline to achieve a new level of integration in digestive biology, pathobiology, and therapy. The scientific focus is on the molecular controls of cellular growth and differentiation in digestive organs and on the relationship of these processes to inflammatory and neoplastic diseases. The research base was refined by a process of discussion, exchanges of reagents, and scientific collaborations between investigators. The number of investigators was decreased from 35 in the initial proposal to 26 scientists who want to further develop an interactive research group. Within the scientific focus, a number of themes have evolved which link Center investigators together, including gene regulation, inflammation and immunology, and regulation of cell growth and tumor biology. Four scientific Cores have been developed with the goals of providing digestive-specific services and reagents and stimulating collaborative research. The cores include Morphology, Molecular Biology, Transgenic and Chimeric Mouse, and Vector. An administrative Core will be led by the Director, Peter G. Traber, and the Scientific/Associate Director, Rebecca A. Traub. This Core will direct the financial and organizational aspects of the center, including development of an enrichment program and electronic communications. Pilot/Feasibility Projects were selected based on their relevance to the scientific focus and the priority of promoting digestive research among young investigators. The proposals include: 1) positional cloning of the gene responsible for the Alagille Syndrome, 2) PRL-1 in intestinal development, 3) induction and patterning of endodermal lineages in Xenopus laevis, and 4) response syndrome. In addition to the Principal Investigators of these proposals, there is a cadre of outstanding young investigators who will benefit from a Digestive Diseases Center at University of Pennsylvania. In summary, this revised proposal provides evidence that the nascent Center proposed two years ago has matured and developed into an entity within the University scientific community. The University of Pennsylvania is poised to take excellent advantage of funding for a Digestive Disease Research Core Center.