CENTER FOR DIGESTIVE AND LIVER DISEASES

修订后的消化疾病研究核心中心提案将联合 来自多个学科的研究人员达到了新的水平 消化生物学、病理学和治疗的整合。的 科学重点是细胞生长的分子控制和 消化器官的分化及其相互关系 炎症和肿瘤性疾病的过程。研究基地是 通过讨论、交换试剂和 研究人员之间的科学合作。数量 调查员人数从最初提案中的 35 人减少到 26 人 想要进一步发展互动研究小组的科学家。 在科学焦点范围内，已经发展出许多主题，这些主题将 中心研究人员聚集在一起，包括基因调控、炎症 免疫学以及细胞生长和肿瘤生物学的调节。四 科学核心的开发目标是提供 消化系统特定服务和试剂并促进协作 研究。核心包括形态学、分子生物学、转基因 和嵌合小鼠和载体。行政核心将由以下人员领导 主任 Peter G. Traber 和科学/副主任， 丽贝卡·A·特劳布该核心将指导财务和组织 该中心的各个方面，包括制定丰富计划 和电子通讯。选择试点/可行性项目 基于它们与科学焦点和优先事项的相关性 促进年轻研究人员的消化研究。提案 包括：1）负责Alagille的基因的定位克隆 综合征，2) PRL-1 在肠道发育中的作用，3) 诱导和 非洲爪蟾内胚层谱系的模式，以及 4) 反应 综合症。除了这些提案的首席研究员之外， 有一支优秀的年轻研究者骨干队伍，他们将受益 来自宾夕法尼亚大学消化疾病中心。在 总之，这一修订后的提案提供了证据表明，新生的 两年前提出的中心已经成熟并发展成为一个实体 在大学科学界内。大学 宾夕法尼亚州准备充分利用资金来 消化疾病研究核心中心。

This revised Digestive Diseases Research Core Center proposal will unite investigators from multiple discipline to achieve a new level of integration in digestive biology, pathobiology, and therapy. The scientific focus is on the molecular controls of cellular growth and differentiation in digestive organs and on the relationship of these processes to inflammatory and neoplastic diseases. The research base was refined by a process of discussion, exchanges of reagents, and scientific collaborations between investigators. The number of investigators was decreased from 35 in the initial proposal to 26 scientists who want to further develop an interactive research group. Within the scientific focus, a number of themes have evolved which link Center investigators together, including gene regulation, inflammation and immunology, and regulation of cell growth and tumor biology. Four scientific Cores have been developed with the goals of providing digestive-specific services and reagents and stimulating collaborative research. The cores include Morphology, Molecular Biology, Transgenic and Chimeric Mouse, and Vector. An administrative Core will be led by the Director, Peter G. Traber, and the Scientific/Associate Director, Rebecca A. Traub. This Core will direct the financial and organizational aspects of the center, including development of an enrichment program and electronic communications. Pilot/Feasibility Projects were selected based on their relevance to the scientific focus and the priority of promoting digestive research among young investigators. The proposals include: 1) positional cloning of the gene responsible for the Alagille Syndrome, 2) PRL-1 in intestinal development, 3) induction and patterning of endodermal lineages in Xenopus laevis, and 4) response syndrome. In addition to the Principal Investigators of these proposals, there is a cadre of outstanding young investigators who will benefit from a Digestive Diseases Center at University of Pennsylvania. In summary, this revised proposal provides evidence that the nascent Center proposed two years ago has matured and developed into an entity within the University scientific community. The University of Pennsylvania is poised to take excellent advantage of funding for a Digestive Disease Research Core Center.