REGULATION IN MULTIGENE FAMILIES

这是一项继续PO 1-GM 31689的资金申请。中央 该提案的目标涉及多基因内的基因调控， 家庭，这代表了四个人的共同利益 独立调查员参与。 强大的技术， 四个实验室利用重组DNA技术研究 生物学上重要的大分子的不同群体。大多数这些 分子是多基因家族的成员，这些家族在一个 发育时期的时尚所有项目的一个关键方面是组织- 蛋白质生产的特殊调节。项目机制 要求的技术，需要执行每个人， 项目不仅需要几个人的智力互动， 调查人员，但此外，资源和设备的集中。 由于该计划项目是提交其第十一至第十五年， 在这方面，这一筹资机制取得了非常重要的成果。 我们四个人将在大约10个月内搬去一个楼层 一个正在建设中的生物医学研究设施 尽管我们最初与不同的部门和不同的 研究生课程，我们将被安置在一起，作为一个“分子免疫学” 中心”。这将进一步促进智力和身体的互动， 提供了我们长期有效互动的有说服力的证据。

This represents a request for funds to continue PO1-GM31689. The central goals of this proposal concern the regulation of genes within multigene families, which represents the common interest among the four participating independent investigators. The powerful techniques of recombinant DNA technology are utilized by the four laboratories to study distinct groups of biologically important macromolecules. Most of these molecules are members of multigene families that are expressed in a developmentally-timed fashion. A key aspect of all projects is the tissue- specific regulation of protein production. The program project mechanism is requested as the technologies needed to carry out each individual project require not only the intellectual interaction of several investigators, but in addition, the pooling of resources and equipment. As this program project is submitted for its eleventh to fifteenth year of support, a very significant outcome of this funding mechanism has emerged. The four of us will be moving in approximately 10 months to occupy a floor of a biomedical research facility that is currently under construction. Despite our initial association with different departments and different graduate programs, we will be housed together as a "Molecular Immunology Center". This will further interactions both intellectual and physical and provides persuasive evidence of our long standing productive interaction.