SOURCES AND PATHWAYS OF PERSISTENT CHLORINATED HYDROCARBON EXPOSURE IN NYC

纽约市持续接触氯化烃的来源和途径

• 批准号: 6239739
• 负责人: RICHARD BOPP
• 金额: $ 11.25万
• 依托单位: MOUNT SINAI SCHOOL OF MEDICINE OF CUNY
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-04-01 至 1998-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6239739
• 关键词: chlorohydrocarbon; environmental contamination; halobiphenyl /halotriphenyl compound; hazardous substances; industrial waste; urban area; water environment

Manufacture and use of PCBs, DDT and other persistent chlorinated hydrocarbons have ceased in the United States. However, very large quantities of these toxic and potentially carcinogenic compounds remain dispersed in the environment where their distribution and fate are imperfectly characterized. Moreover, additional PCBs and other organochlorines continue to be added to the environment, particularly to natural waters where they contaminate the sediments and can be taken up by fish and then by humans. To investigate current sources of PCBs, DDT-derived compounds, and chlordane to the natural waters adjacent to New York City, analyses of dated sediment core sections and sewage-related samples will be performed. Data from sewage sludge samples will be used to characterize local sources of chlorinated organic hydrocarbons. Contaminant levels in sediments will be interpreted on the basis of sewage sludge data and known industrial sources. Temporal trends in contaminant levels throughout the NY-NJ harbor complex will be determined through the analysis of dated sediment cores. Comparisons of PCB compositions in archived and recent sediment core samples will be used to elucidate the rates and pathways of in situ reductive dechlorination, a process that reduces the carcinogenic toxicity of PCBs and forms the basis of several new remediation technologies. The levels of persistent chlorinated hydrocarbons in sediments and their temporal trends are an excellent indicator of the levels and trends in fish. Since fish consumption is a major pathway of human exposure, the project relates to a significant health concern. Extracts of representative contaminated sediments will be supplied for projects 6, 7, and 8 which address direct links between contaminant exposure and human breast cancer.

多氯联苯、滴滴涕及其他持久性氯联苯的生产和使用 碳氢化合物在美国已经停止。 然而，非常大 这些有毒和潜在致癌化合物的数量仍然存在 分散在环境中，它们的分布和命运 不完美的特点。 此外，额外的多氯联苯和其他 有机氯继续被添加到环境中，特别是 天然沃茨，污染沉积物， 先是鱼类，然后是人类。 调查目前多氯联苯、滴滴涕衍生化合物和 对纽约市附近天然沃茨中的三氯甲烷的分析 过时的沉积物核心部分和污水相关的样本将被 执行。 污水污泥样品的数据将用于表征 氯化有机碳氢化合物的本地来源。 污染物水平 将根据污水污泥数据解释沉积物中的 已知的工业来源。 纽约-新泽西港口综合体污染物水平的时间趋势 将通过分析过时的沉积物岩心来确定。 沉积物柱状样中多氯联苯组分的比较 样品将被用来阐明的速率和途径，在原位 还原脱氯，一个减少致癌物质 多氯联苯的毒性，并形成了一些新的补救措施的基础 技术. 沉积物中持久性氯代烃的水平及其影响因素 时间趋势是一个很好的指标的水平和趋势， 鱼. 由于食用鱼类是人类接触的主要途径， 项目涉及重大健康问题。 提取物 将为项目6提供具有代表性的受污染沉积物， 7和8，其中涉及污染物暴露和 人类乳腺癌