SOURCES AND PATHWAYS OF PERSISTENT CHLORINATED HYDROCARBON EXPOSURE IN NYC

多氯联苯、滴滴涕等持久性氯化产品的生产和使用 碳氢化合物在美国已经停止使用。然而，非常大的 这些有毒和潜在致癌化合物的数量仍然存在 分散在它们的分布和命运所在的环境中 不完美的特征。此外，额外的多氯联苯和其他 有机氯化合物继续被添加到环境中，特别是 它们污染沉积物并可被吸收的天然水域 先是鱼，然后是人类。 调查多氯联苯、滴滴涕衍生化合物和 氯丹对纽约市附近的自然水域的分析 沉积物岩心切片和与污水有关的样本将 已执行。来自污水污泥样本的数据将被用来表征 氯化有机碳氢化合物的本地来源。污染物水平 将根据污水污泥数据和 已知的工业来源。 整个纽约-新泽西州港口综合体污染物水平的时间趋势 将通过对沉积物岩心年代的分析来确定。 存档岩心与现代沉积岩心中印刷电路板成分的对比 样本将被用来阐明原位反应的速率和途径 还原脱氯，一种减少致癌物质的过程 多氯联苯的毒性，并构成了几种新的补救措施的基础 技术。 沉积物中持久性氯代烃的含量及其影响因素 时间趋势是反映以下方面水平和趋势的极佳指标 鱼。由于食用鱼类是人类接触的主要途径， 该项目涉及一个重大的健康问题。植物精华 有代表性的污染沉积物将被提供给项目6， 7和8，它们处理污染物暴露和 人类乳腺癌。

Manufacture and use of PCBs, DDT and other persistent chlorinated hydrocarbons have ceased in the United States. However, very large quantities of these toxic and potentially carcinogenic compounds remain dispersed in the environment where their distribution and fate are imperfectly characterized. Moreover, additional PCBs and other organochlorines continue to be added to the environment, particularly to natural waters where they contaminate the sediments and can be taken up by fish and then by humans. To investigate current sources of PCBs, DDT-derived compounds, and chlordane to the natural waters adjacent to New York City, analyses of dated sediment core sections and sewage-related samples will be performed. Data from sewage sludge samples will be used to characterize local sources of chlorinated organic hydrocarbons. Contaminant levels in sediments will be interpreted on the basis of sewage sludge data and known industrial sources. Temporal trends in contaminant levels throughout the NY-NJ harbor complex will be determined through the analysis of dated sediment cores. Comparisons of PCB compositions in archived and recent sediment core samples will be used to elucidate the rates and pathways of in situ reductive dechlorination, a process that reduces the carcinogenic toxicity of PCBs and forms the basis of several new remediation technologies. The levels of persistent chlorinated hydrocarbons in sediments and their temporal trends are an excellent indicator of the levels and trends in fish. Since fish consumption is a major pathway of human exposure, the project relates to a significant health concern. Extracts of representative contaminated sediments will be supplied for projects 6, 7, and 8 which address direct links between contaminant exposure and human breast cancer.