Air Pollution Impacts on Cardiopulmonary Disease in Beijing: An integrated study of Exposure Science, Toxicogenomics and Environmental Epidemiology

北京空气污染对心肺疾病的影响:暴露科学、毒理基因组学和环境流行病学的综合研究

基本信息

  • 批准号:
    NE/N007182/1
  • 负责人:
  • 金额:
    $ 63.09万
  • 依托单位:
  • 依托单位国家:
    英国
  • 项目类别:
    Research Grant
  • 财政年份:
    2016
  • 资助国家:
    英国
  • 起止时间:
    2016 至 无数据
  • 项目状态:
    已结题

项目摘要

This proposal aims to do a comprehensive evaluation of air pollution health impacts on cardiopulmonary health through integration of exposure, epidemiology, and toxicology/toxicogenomic studies. We will do detailed assessments of people's exposure to air pollution, estimating exposures for long- and short-term epidemiological analyses, and linking these to epidemiological analyses of long term health impacts based on a cohort study, short-term effects (i.e. biomarkers, blood pressure, heart rhythm, peak flow) based on a panel study, and early life effects based on a birth cohort. Additionally, we test the effect of reducing exposure to fine particles, but not gases, by designing an intervention study where volunteers will wear a face mask and examining the exposure-response relationship for the same short-term effects we evaluate in the panel study. The short-term physiological measurements we conduct in the epidemiological studies will provide insight into the mechanisms by which air pollutions affects cardiopulmonary health. To complement the human based studies into mechanisms of action, our project will also conduct extensive in vivo analyses of mechanistic effects, and early life toxicogenomics/metabonomics. Finally, we will provide practical advice to stakeholders based on our study findings, by assessing the potential value of selected strategies for control of exposure to outdoor health protection in a health risk assessment.
该提案旨在通过整合暴露、流行病学和毒理学/毒理基因组学研究,全面评估空气污染对心肺健康的影响。我们将对人们暴露于空气污染的情况进行详细评估,为长期和短期流行病学分析估算暴露情况,并将这些评估与基于队列研究的长期健康影响、基于小组研究的短期影响(即生物标志物、血压、心律、峰值流量)以及基于出生队列的早期生命影响的流行病学分析联系起来。此外,我们通过设计一项干预研究来测试减少暴露于细颗粒物而不是气体的效果,其中志愿者将佩戴口罩,并检查我们在小组研究中评估的相同短期影响的安全性-反应关系。我们在流行病学研究中进行的短期生理测量将深入了解空气污染影响心肺健康的机制。为了补充对作用机制的人体研究,我们的项目还将对机制效应和早期生命毒理基因组学/代谢组学进行广泛的体内分析。最后,我们将根据我们的研究结果,通过评估健康风险评估中控制户外健康保护暴露的选定策略的潜在价值,为利益相关者提供实用的建议。

项目成果

期刊论文数量(10)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Inflammation-coagulation response and thrombotic effects induced by silica nanoparticles in zebrafish embryos.
  • DOI:
    10.1080/17435390.2018.1461267
  • 发表时间:
    2018-06
  • 期刊:
  • 影响因子:
    5
  • 作者:
    Duan J;Liang S;Yu Y;Li Y;Wang L;Wu Z;Chen Y;Miller MR;Sun Z
  • 通讯作者:
    Sun Z
Street-scale air quality modelling for Beijing during a winter 2016 measurement campaign
  • DOI:
    10.5194/acp-2019-783
  • 发表时间:
    2019-09
  • 期刊:
  • 影响因子:
    6.3
  • 作者:
    M. Biggart;J. Stocker;R. Doherty;O. Wild;M. Hollaway;Davis Carruthers;Jie Li;Qiang Zhang;
  • 通讯作者:
    M. Biggart;J. Stocker;R. Doherty;O. Wild;M. Hollaway;Davis Carruthers;Jie Li;Qiang Zhang;
In-mask temperature and humidity can validate respirator wear-time and indicate lung health status.
{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ monograph.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ sciAawards.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ conferencePapers.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ patent.updateTime }}

Miranda Loh其他文献

100. Condom Use and Discontinuation among Adolescents Using Long-Acting Reversible Contraception
  • DOI:
    10.1016/j.jadohealth.2022.01.195
  • 发表时间:
    2022-04-01
  • 期刊:
  • 影响因子:
  • 作者:
    Miranda Loh;Li Niu;Martha Arden;Nicolas Schlecht
  • 通讯作者:
    Nicolas Schlecht
The relationship between greenspace and personal exposure to PMsub2.5/sub during walking trips in Delhi, India
印度德里步行出行期间绿地与个人接触 PM2.5 之间的关系
  • DOI:
    10.1016/j.envpol.2022.119294
  • 发表时间:
    2022-07-15
  • 期刊:
  • 影响因子:
    7.300
  • 作者:
    William Mueller;Paul Wilkinson;James Milner;Miranda Loh;Sotiris Vardoulakis;Zoë Petard;Mark Cherrie;Naveen Puttaswamy;Kalpana Balakrishnan;D.K. Arvind
  • 通讯作者:
    D.K. Arvind
Intake Fraction Variability Between Air Pollution Emission Sources Inside an Urban Area
城市区域内空气污染排放源之间的吸入分数变化
  • DOI:
  • 发表时间:
    2014
  • 期刊:
  • 影响因子:
    3.8
  • 作者:
    M. Tainio;P. Holnicki;Miranda Loh;Z. Nahorski
  • 通讯作者:
    Z. Nahorski
Facemask use for community protection from air pollution disasters: An ethical overview and framework to guide agency decision making
使用口罩保护社区免受空气污染灾难:指导机构决策的道德概述和框架
  • DOI:
    10.1016/j.ijdrr.2019.101376
  • 发表时间:
    2020
  • 期刊:
  • 影响因子:
    5
  • 作者:
    F. McDonald;C. Horwell;Richard Wecker;L. Dominelli;Miranda Loh;R. Kamanyire;C. Ugarte
  • 通讯作者:
    C. Ugarte
Transdisciplinary Research as a Means of Protecting Human Health, Ecosystems and Climate by Engaging People to Act on Air Pollution
跨学科研究作为通过让人们对空气污染采取行动来保护人类健康、生态系统和气候的一种手段
  • DOI:
    10.1079/onehealthcases.2024.0002
  • 发表时间:
    2024
  • 期刊:
  • 影响因子:
    0
  • 作者:
    P. Büker;Sarah E. West;Cressida Bowyer;William Apondo;S. Cinderby;C. Gray;Matthew Hahn;Fiona Lambe;Miranda Loh;Alexander J. Medcalf;C. Muhoza;Kanyiva Muindi;T. Njoora;M. Twigg;Charlotte Waelde;Anna Walnycki;Megan Wainwright;Jana Wendler;Mike Wilson;Heather D. Price
  • 通讯作者:
    Heather D. Price

Miranda Loh的其他文献

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

{{ truncateString('Miranda Loh', 18)}}的其他基金

Citizens' Data for Air Pollution (CitiDAir)
公民空气污染数据 (CitiDAir)
  • 批准号:
    BB/T019301/1
  • 财政年份:
    2020
  • 资助金额:
    $ 63.09万
  • 项目类别:
    Research Grant

相似海外基金

Health effects of low-concentration, non-urban air pollution: health impacts of ship emission controls
低浓度非城市空气污染对健康的影响:船舶排放控制对健康的影响
  • 批准号:
    23H03158
  • 财政年份:
    2023
  • 资助金额:
    $ 63.09万
  • 项目类别:
    Grant-in-Aid for Scientific Research (B)
Impacts of Air Pollution from Ultrafine Tire-Wear Particles on Cardiorespiratory Health
超细轮胎磨损颗粒造成的空气污染对心肺健康的影响
  • 批准号:
    2899750
  • 财政年份:
    2023
  • 资助金额:
    $ 63.09万
  • 项目类别:
    Studentship
Impacts of Acute Ambient Air Pollution Exposure on Women's Reproductive Health: Identifying Mechanisms and Susceptible Reproductive Processes Across the Menstrual Cycle and Early Pregnancy
急性环境空气污染暴露对女性生殖健康的影响:确定月经周期和怀孕早期的机制和易受影响的生殖过程
  • 批准号:
    10645818
  • 财政年份:
    2023
  • 资助金额:
    $ 63.09万
  • 项目类别:
Biomarkers of inflammation across the lung to brain axis as mediators of the adverse impacts of air pollution on brain health
肺到脑轴炎症的生物标志物作为空气污染对大脑健康不利影响的介质
  • 批准号:
    2899572
  • 财政年份:
    2023
  • 资助金额:
    $ 63.09万
  • 项目类别:
    Studentship
Characterizing the sources and impacts of air pollution for vulnerable populations: a three-pronged field monitoring study in Vancouver, Canada
描述空气污染的来源和对弱势群体的影响:加拿大温哥华的三管齐下的实地监测研究
  • 批准号:
    575514-2022
  • 财政年份:
    2022
  • 资助金额:
    $ 63.09万
  • 项目类别:
    Alexander Graham Bell Canada Graduate Scholarships - Master's
Characterizing source impacts and trend of air pollution
描述空气污染的来源影响和趋势
  • 批准号:
    RGPIN-2020-05761
  • 财政年份:
    2022
  • 资助金额:
    $ 63.09万
  • 项目类别:
    Discovery Grants Program - Individual
Community Scenarios Of Hydrogen Energy And Impacts On Air Pollution
氢能的社区场景及其对空气污染的影响
  • 批准号:
    NE/X01343X/1
  • 财政年份:
    2022
  • 资助金额:
    $ 63.09万
  • 项目类别:
    Research Grant
Activation, recurrence, and mortality: Exploring impacts of air pollution and greenness on progressions of latent and active tuberculosis to inform interventions.
激活、复发和死亡率:探索空气污染和绿色对潜伏性和活动性结核病进展的影响,为干预措施提供信息。
  • 批准号:
    468526
  • 财政年份:
    2022
  • 资助金额:
    $ 63.09万
  • 项目类别:
    Operating Grants
Characterizing source impacts and trend of air pollution
描述空气污染的来源影响和趋势
  • 批准号:
    RGPIN-2020-05761
  • 财政年份:
    2021
  • 资助金额:
    $ 63.09万
  • 项目类别:
    Discovery Grants Program - Individual
CAREER: Leveraging Complex Variables to Refine Estimates of Air Pollution Emissions and their Impacts under Uncertainty
职业:利用复杂变量来完善对空气污染排放及其在不确定性下的影响的估计
  • 批准号:
    1944669
  • 财政年份:
    2020
  • 资助金额:
    $ 63.09万
  • 项目类别:
    Continuing Grant
{{ showInfoDetail.title }}

作者:{{ showInfoDetail.author }}

知道了