Air Pollution Impacts on Cardiopulmonary Disease in Beijing: An integrated study of Exposure Science, Toxicogenomics and Environmental Epidemiology

北京空气污染对心肺疾病的影响：暴露科学、毒理基因组学和环境流行病学的综合研究

• 批准号: NE/N007182/1
• 负责人: Miranda Loh
• 金额: $ 63.09万
• 依托单位: Institute of Occupational Medicine
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2016
• 资助国家: 英国
• 起止时间: 2016 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=NE%2FN007182%2F1
• 关键词: Air; Pollution; Impacts; Cardiopulmonary; Disease

This proposal aims to do a comprehensive evaluation of air pollution health impacts on cardiopulmonary health through integration of exposure, epidemiology, and toxicology/toxicogenomic studies. We will do detailed assessments of people's exposure to air pollution, estimating exposures for long- and short-term epidemiological analyses, and linking these to epidemiological analyses of long term health impacts based on a cohort study, short-term effects (i.e. biomarkers, blood pressure, heart rhythm, peak flow) based on a panel study, and early life effects based on a birth cohort. Additionally, we test the effect of reducing exposure to fine particles, but not gases, by designing an intervention study where volunteers will wear a face mask and examining the exposure-response relationship for the same short-term effects we evaluate in the panel study. The short-term physiological measurements we conduct in the epidemiological studies will provide insight into the mechanisms by which air pollutions affects cardiopulmonary health. To complement the human based studies into mechanisms of action, our project will also conduct extensive in vivo analyses of mechanistic effects, and early life toxicogenomics/metabonomics. Finally, we will provide practical advice to stakeholders based on our study findings, by assessing the potential value of selected strategies for control of exposure to outdoor health protection in a health risk assessment.

该提案旨在通过整合暴露、流行病学和毒理学/毒理基因组学研究，全面评估空气污染对心肺健康的影响。我们将对人们暴露于空气污染的情况进行详细评估，为长期和短期流行病学分析估算暴露情况，并将这些评估与基于队列研究的长期健康影响、基于小组研究的短期影响（即生物标志物、血压、心律、峰值流量）以及基于出生队列的早期生命影响的流行病学分析联系起来。此外，我们通过设计一项干预研究来测试减少暴露于细颗粒物而不是气体的效果，其中志愿者将佩戴口罩，并检查我们在小组研究中评估的相同短期影响的安全性-反应关系。我们在流行病学研究中进行的短期生理测量将深入了解空气污染影响心肺健康的机制。为了补充对作用机制的人体研究，我们的项目还将对机制效应和早期生命毒理基因组学/代谢组学进行广泛的体内分析。最后，我们将根据我们的研究结果，通过评估健康风险评估中控制户外健康保护暴露的选定策略的潜在价值，为利益相关者提供实用的建议。

项目成果

Inflammation-coagulation response and thrombotic effects induced by silica nanoparticles in zebrafish embryos.

• DOI: 10.1080/17435390.2018.1461267
• 发表时间: 2018-06
• 期刊: Nanotoxicology
• 影响因子: 5
• 作者: Duan J;Liang S;Yu Y;Li Y;Wang L;Wu Z;Chen Y;Miller MR;Sun Z
• 通讯作者: Sun Z

Street-scale air quality modelling for Beijing during a winter 2016 measurement campaign

• DOI: 10.5194/acp-2019-783
• 发表时间: 2019-09
• 期刊: Atmospheric Chemistry and Physics
• 影响因子: 6.3
• 作者: M. Biggart;J. Stocker;R. Doherty;O. Wild;M. Hollaway;Davis Carruthers;Jie Li;Qiang Zhang

In-mask temperature and humidity can validate respirator wear-time and indicate lung health status.

• DOI: 10.1038/s41370-018-0089-y
• 发表时间: 2019-06
• 期刊: Journal of exposure science & environmental epidemiology
• 影响因子: 4.5
• 作者: Cherrie JW;Wang S;Mueller W;Wendelboe-Nelson C;Loh M
• 通讯作者: Loh M