Air Pollution Impacts on Cardiopulmonary Disease in Beijing: An integrated study of Exposure Science, Toxicogenomics and Environmental Epidemiology

北京空气污染对心肺疾病的影响：暴露科学、毒理基因组学和环境流行病学的综合研究

• 批准号: NE/N007182/1
• 负责人: Miranda Loh
• 金额: $ 63.09万
• 依托单位: Institute of Occupational Medicine
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2016
• 资助国家: 英国
• 起止时间: 2016 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=NE%2FN007182%2F1
• 关键词: Air; Pollution; Impacts; Cardiopulmonary; Disease

This proposal aims to do a comprehensive evaluation of air pollution health impacts on cardiopulmonary health through integration of exposure, epidemiology, and toxicology/toxicogenomic studies. We will do detailed assessments of people's exposure to air pollution, estimating exposures for long- and short-term epidemiological analyses, and linking these to epidemiological analyses of long term health impacts based on a cohort study, short-term effects (i.e. biomarkers, blood pressure, heart rhythm, peak flow) based on a panel study, and early life effects based on a birth cohort. Additionally, we test the effect of reducing exposure to fine particles, but not gases, by designing an intervention study where volunteers will wear a face mask and examining the exposure-response relationship for the same short-term effects we evaluate in the panel study. The short-term physiological measurements we conduct in the epidemiological studies will provide insight into the mechanisms by which air pollutions affects cardiopulmonary health. To complement the human based studies into mechanisms of action, our project will also conduct extensive in vivo analyses of mechanistic effects, and early life toxicogenomics/metabonomics. Finally, we will provide practical advice to stakeholders based on our study findings, by assessing the potential value of selected strategies for control of exposure to outdoor health protection in a health risk assessment.

本提案旨在整合暴露、流行病学和毒理学/毒物基因组学研究，对空气污染对心肺健康的影响进行综合评估。我们将对人们暴露于空气污染的情况进行详细评估，估计长期和短期流行病学分析的暴露情况，并将这些与基于队列研究的长期健康影响的流行病学分析、基于小组研究的短期影响（即生物标志物、血压、心律、峰值血流）以及基于出生队列的早期生活影响联系起来。此外，我们通过设计一项干预研究来测试减少接触细颗粒（而不是气体）的效果，在这项研究中，志愿者将戴上口罩，并检查暴露-反应关系，以获得与我们在小组研究中评估的相同的短期影响。我们在流行病学研究中进行的短期生理测量将为了解空气污染影响心肺健康的机制提供见解。为了补充基于人体的作用机制研究，我们的项目还将进行广泛的体内机制效应分析，以及早期生命毒性基因组学/代谢组学。最后，我们将根据我们的研究结果，通过在健康风险评估中评估控制户外健康保护暴露的选定战略的潜在价值，向利益攸关方提供实用建议。

项目成果

Inflammation-coagulation response and thrombotic effects induced by silica nanoparticles in zebrafish embryos.

• DOI: 10.1080/17435390.2018.1461267
• 发表时间: 2018-06
• 期刊: Nanotoxicology
• 影响因子: 5
• 作者: Duan J;Liang S;Yu Y;Li Y;Wang L;Wu Z;Chen Y;Miller MR;Sun Z
• 通讯作者: Sun Z

Street-scale air quality modelling for Beijing during a winter 2016 measurement campaign

• DOI: 10.5194/acp-2019-783
• 发表时间: 2019-09
• 期刊: Atmospheric Chemistry and Physics
• 影响因子: 6.3
• 作者: M. Biggart;J. Stocker;R. Doherty;O. Wild;M. Hollaway;Davis Carruthers;Jie Li;Qiang Zhang

In-mask temperature and humidity can validate respirator wear-time and indicate lung health status.

• DOI: 10.1038/s41370-018-0089-y
• 发表时间: 2019-06
• 期刊: Journal of exposure science & environmental epidemiology
• 影响因子: 4.5
• 作者: Cherrie JW;Wang S;Mueller W;Wendelboe-Nelson C;Loh M
• 通讯作者: Loh M