SYNTHESIS OF POLYMERS AS MIMICS FOR BIOLOGICAL MEMBRANES AND CHIRAL MOLECULES

作为生物膜和手性分子模拟物的聚合物的合成

• 批准号: 6240341
• 负责人: Ishrat M Khan
• 金额: $ 11.79万
• 依托单位: CLARK ATLANTA UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-02-01 至 1998-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6240341
• 关键词: artificial membranes; biosensor device; chemical structure function; chemical synthesis; chemical transfer reaction; copolymer I; membrane model; stereochemistry; stereoisomer; technology /technique

The general research plan of our effort is to develop polymeric materials that mimic biological systems. We are currently concentrating on the development of polymers which function on the basis of noncovalent interactions and/or electron transfer processes. The first objective of the work will be to develop and economically feasible methodology for preparing optically active vinyl polymers or helix sense selective polymerization. Computational and experimental techniques will be used in a complementary fashion to develop this methodology. By studying monomer structure-tendency to isotactic polymerization and conformational stabilities of the resulting isotactic polymers, we expect to develop this methodology. Inexpensive optically active polymers will be useful in molecular biology, synthetic enzymes and regenerable asymmetric reagents. Secondly, we intent to further develop the MIEC block copolymers as the active component in biosensors to detect and quantify enantiomers of amino acids through noncovalent interactions. We will, also, evaluate and develop the MIEC block copolymers for biological electron transfer membranes. It is expected this work will result in the preparation of synthetic membranes for therapeutic purposes.

我们努力的总体研究计划是开发聚合物材料 模仿生物系统的机器人 我们目前正在集中精力， 基于非共价键的功能聚合物的开发 相互作用和/或电子转移过程。 这项工作的第一个目标将是发展和经济 制备光学活性乙烯基聚合物的可行方法， 螺旋定向选择性聚合。 计算和实验 技术将以互补的方式用于开发这一点， 方法论 通过研究单体结构向全同立构的趋势， 所得全同立构的聚合和构象稳定性 聚合物，我们希望开发这种方法。 光学价格低廉 活性聚合物在分子生物学、合成酶 和可再生的不对称试剂。 其次，我们打算进一步 开发MIEC嵌段共聚物作为生物传感器的活性组分 通过非共价键检测和定量氨基酸的对映体 交互. 我们还将评估和开发MIEC块 用于生物电子传递膜的共聚物。 预计 这项工作将导致合成膜的制备， 治疗目的。