Studies on biosensor device technology based on immobilization of intact liposome on Si-integrated sensor structure

我们研究了一系列基于完整脂质体固定在硅集成传感器结构上的生物传感器器件技术。因此，固定化脂质体保持其完整的行为超过24小时，这对于通常的传感来说实际上是很长的时间范围。在此基础上，设计、制作了微热计、生化传感器、漏电流传感器和悬臂应变传感器三种脂质体生物传感器，并对其用于靶蛋白的检测进行了评价。最后对这些传感器进行了验证，显示了其有效的传感性能。

We have studied a series of biosensor device technologies based on immobilization of intact liposome on Si-integrated sensor structure. As a result, the immobilized liposome keeps its intact behavior more than 24hrs, meaning practically long time range for usual sensing. Based on the result, three type of liposome biosensor of microbolometer biothermochemical sensor, leakage current sensor and cantilever strain sensor are designed, fabricated and evaluated for detection of target proteins. Finally these sensors are confirmed to show their effective sensing performance.