REGULATION OF PHARYNGEAL MUSCLE CONTRACTION

咽部肌肉收缩的调节

• 批准号: 6109962
• 负责人: ERIK VAN LUNTEREN
• 金额: $ 12.67万
• 依托单位: CASE WESTERN RESERVE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-09-01 至 1999-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6109962
• 关键词: aminopyridines; attention; diaphragm; disease /disorder proneness /risk; electrophysiology; human subject; longitudinal human study; muscle contraction; nervous system disorder chemotherapy; nervous system disorder diagnosis; pharynxs; potassium channel; psychomotor function; respiratory airway pressure; sleep apnea; sleep disorders; tetraethylammonium compound; wakefulness

Frequent sleep-related respiratory disturbances (SRRD) have been recognized to occur in as many as 70% of elderly and 15% of middle-aged subjects. Although it is widely agreed that subjects with obvious daytime sleepiness that occurs in association with severe obstructive sleep apnea (Respiratory disturbance indices (RDI) >30) benefit from treatment of their sleep disorders; there is no consensus (and a paucity of data) regarding treatment benefits in subjects with a less profound disorder. Rational utilization of health care resources for diagnosis and treatment of sleep apnea requires assessment of whether adverse health effects occur as a consequence of mild or moderate levels of SRRD, and whether any such health effects may be reversible with treatment. In this study, we propose to determine the degree to which neuro- psychological performance and general health status and function may be impaired in subjects with mild and moderate degrees of SRRD, as compared to subjects with minimal apneic activity. The degree to which improvement may occur following specific treatment will also be assessed. We propose to assess neuropsychological performance, sleepiness and general functional status in 330 subjects, including subjects with little apneic activity (RDI<5), mild activity (RDI 5-14), and moderate activity (RDI 15-25). Of these subjects, 75% will be selected from a clinic-based sample, and 25% will be recruited from an ongoing population-based study. 150 subjects with mild and moderate activity will be randomized to receive "conservative" medical therapy (CMT) or CMT plus nasal CPAP therapy. We will utilize simple statistics, as well as multivariate techniques, to determine the relationship between SRRD (and associated hypoxemia, sleep fragmentation, and physiological sleepiness) to: a) intellectual abilities, attention and vigilance, psychomotor performance, learning and memory, and executive functions, and b) to general health status and function. Potential benefits of treatment specific for sleep apnea in subjects with mild and moderate SRRD will also be determined after two months of CPAP therapy. These data will provide new information about the health effects of mild and moderate sleep apnea that are needed for appropriate clinical decision making and utilization of health care resources.

频繁的睡眠相关呼吸紊乱(SRRD)一直是 被认为发生在多达70%的老年人和15%的中年人 研究对象。尽管人们普遍认为，具有明显 与严重梗阻相关的日间嗜睡 睡眠呼吸暂停(呼吸紊乱指数(RDI)&30)受益于 治疗他们的睡眠障碍；没有共识(而且很少 数据)关于治疗受益的研究对象 无序。合理利用医疗资源为诊断服务 睡眠呼吸暂停的治疗需要评估是否有不良反应 对健康的影响是轻度或中度SRRD的结果， 以及这种对健康的影响是否可以通过治疗而逆转。 在这项研究中，我们建议确定神经- 心理表现和一般健康状况和功能可能是 与轻度和中度SRRD患者相比，SRRD受损 对于呼吸暂停活动量最小的受试者。在多大程度上 还将评估具体治疗后可能出现的改善。 我们建议评估神经心理表现、嗜睡和 330例受试者一般功能状态调查 呼吸暂停活动(RDI&lt；5)、轻度活动(RDI 5-14)和中度活动 (RDI 15-25)。在这些受试者中，75%将从以诊所为基础的 样本，25%将从正在进行的基于人群的研究中招募。 150名轻度和中度活动量的受试者将被随机分配到 接受“保守”药物治疗(CMT)或CMT加鼻腔CPAP 心理治疗。我们将使用简单的统计方法，以及多元统计方法 技术，以确定SRRD(和关联的 低氧血症、睡眠碎片和生理性嗜睡)至：a) 智力，注意力和警觉性，精神运动表现， 学习和记忆，以及执行功能，以及b)总体健康 地位和作用。针对睡眠的特殊治疗的潜在益处 轻度和中度SRRD受试者的呼吸暂停也将被检测 在两个月的CPAP治疗后。这些数据将提供新的 关于轻度和中度睡眠呼吸暂停对健康影响的信息 对于适当的临床决策和利用来说是必要的 卫生保健资源。