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How do sex ratio distorting symbionts affect the evolution of their host?

性别比例扭曲的共生体如何影响宿主的进化？

基本信息

批准号：
NE/N010434/1
负责人：
Gregory Hurst
金额：
$ 58.39万
依托单位：
University of Liverpool
依托单位国家：
英国
项目类别：
Research Grant
财政年份：
2016
资助国家：
英国
起止时间：
2016 至无数据
项目状态：
已结题

来源：
https://gtr.ukri.org/projects?ref=NE%2FN010434%2F1
关键词：
How do sex ratio distorting

项目摘要

The biology of animals is in part a function of the microbes they interact with. During digestion, for instance, food is broken down both by enzymes secreted by our digestive system and those secreted by the microbes that live within the gut. In many insects, microbe-host interactions are even more developed. Bacterial symbionts live inside the cells of the insect body, and these are passed from a female to her offspring via her eggs: heritable symbiosis. We know a lot about how these symbionts affect the individual they infect. One particularly interesting impact is male-killing, where the bacterium passes from a female to her eggs, and kills those which develop as males. We know male-killing bacteria are common: they are present in many species, and, where they are present, can be present in the majority of individuals - this produces insect populations where males are rare. However, we know little about how these bacteria affect insect ecology or evolution. A variety of researchers believe these symbionts may drive changes in the way male and female insects are formed during development, sex determination. The hypothesis is simple - where symbionts target males only, natural selection counteracts this by favouring new ways of making a male that escape male-killing. This study will examine this theory for a recent case of evolution of the blue moon butterfly to avoid the action of male-killing bacterium called Wolbachia. We have documented the spread of a mutation that rescues male blue moon butterflies from Wolbachia-induced death. This project will establish what this mutation is, whether it involves changes in a gene called 'doublesex', which defines male and female characteristics in insects. A second aspect of male-killers is that they may drive very strong natural selection to rescue males. The intensity of selection is such that the changes that occur to rescue males may be otherwise deleterious. A second aim of the project is to establish if this is true, and whether the mutation (beyond rescuing males) degrades male and female function. In completing this project, we will present the first direct test of the theory that the processes that make males/females different can be driven by microbes. This is an enigmatic link that would make clear the interdependence of insect and microbe evolution.

动物的生物学在某种程度上取决于与它们相互作用的微生物。例如，在消化过程中，食物被消化系统分泌的酶和肠道内微生物分泌的酶分解。在许多昆虫中，微生物与宿主的相互作用更加发达。细菌共生体生活在昆虫身体的细胞内，这些细菌通过卵从雌性传递给她的后代：可遗传的共生。我们知道很多关于这些共生体如何影响它们感染的个体。一个特别有趣的影响是杀死雄性，细菌从雌性传到她的卵，杀死那些发育成雄性的卵。我们知道杀死雄性的细菌很常见：它们存在于许多物种中，并且，在它们存在的地方，可以存在于大多数个体中-这产生了雄性罕见的昆虫种群。然而，我们对这些细菌如何影响昆虫生态或进化知之甚少。许多研究人员认为，这些共生体可能会改变雄性和雌性昆虫在发育过程中形成的方式，即性别决定。这个假设很简单--当共生体只针对雄性时，自然选择通过支持新的方式来抵消这一点，使雄性逃脱雄性杀戮。这项研究将检验这一理论的最近的情况下，进化的蓝月亮蝴蝶，以避免行动的男性杀死细菌称为沃尔巴克氏体。我们已经记录了一种突变的传播，这种突变使雄性蓝月亮蝴蝶免于沃尔巴克氏体引起的死亡。该项目将确定这种突变是什么，它是否涉及一种名为“doublemex”的基因的变化，该基因定义了昆虫的雄性和雌性特征。雄性杀手的第二个方面是，它们可能会驱使非常强大的自然选择来拯救雄性。选择的强度是这样的，为了拯救雄性而发生的变化可能是有害的。该项目的第二个目的是确定这是否属实，以及突变（除了拯救男性）是否会降低男性和女性的功能。在完成这个项目，我们将提出的理论，使男性/女性不同的过程可以由微生物驱动的第一个直接测试。这是一个神秘的联系，它将使昆虫和微生物进化的相互依赖变得清晰。