CORE--TRANSGENIC ANIMALS AND ATHEROSCLEROSIS MEASUREMENTS

核心——转基因动物和动脉粥样硬化测量

• 批准号: 6241568
• 负责人: EDWARD M RUBIN
• 金额: $ 36.74万
• 依托单位: UNIVERSITY OF CALIF-LAWRENC BERKELEY LAB
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-09-30 至 1998-09-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6241568
• 关键词: artificial chromosomes; atherosclerosis; biomedical facility; gene targeting; genetically modified animals; immunocytochemistry; laboratory mouse; morphology; plasmids; transfection; transfection /expression vector

Core B will support the projects in two major ways: a) preparation of transgenic mice; b) designing atherogenesis studies and performing qualitative and quantitative morphological and immunohistochemical analysis of mouse tissues including atherosclerotic lesions. Related to this, the core will assist Project in planning transgenesis and atherogenesis studies, and provide technical support in the genetic engineering of mice and analysis of their tissues. The core will also maintain and provide to the Projects various mice engineered by the Rubin Laboratory or created elsewhere, for planned atherogenic studies.

核心项目B将以两种主要方式支持这些项目： 转基因小鼠; B）设计动脉粥样硬化形成研究并进行 定性和定量形态学和免疫组织化学 包括动脉粥样硬化病变的小鼠组织的分析。 有关 这一点，核心将协助项目规划转基因， 动脉粥样硬化的研究，并提供技术支持，在遗传 小鼠的工程化及其组织分析。 核心还将 维护并向项目提供由 Rubin实验室或其他地方创建，用于计划性动脉粥样硬化 问题研究