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CORE--GERIATRIC CLINICAL PSYCHOPHARMACOLOGY

CORE--GERIATRIC CLINICAL PSYCHOPHARMACOLOGY
核心--老年临床精神药理学
批准号：
6243284
负责人：
BRUCE G POLLOCK
金额：
$21.9万
依托单位：
UNIVERSITY OF PITTSBURGH AT PITTSBURGH
依托单位国家：
美国
项目类别：
财政年份：
1997
资助国家：
美国
项目状态：
已结题
起止时间：
1997-03-01 至 1998-02-28
来源：
https://reporter.nih.gov/project-details/6243284
关键词：
aging antidepressants attention biomedical facility clinical trials cognition cytochrome P450 human old age (65+) human subject human therapy evaluation major depression memory neuropsychological tests nortriptyline paroxetine pharmacokinetics phenotype psychomotor function psychopharmacology

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中文摘要
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英文摘要
This Core focuses on antidepressant studies and is particularly concerned with the assay of nortriptyline and paroxetine platelet 5-HT reuptake interrupted by the use of antidepressant medication, including a double- blind study of paroxetine, a potent innovative serotonin reuptake inhibitor versus the more generally used nortriptyline. The goal of the study is to document pharmacokinetic changes in elderly adults. one primary goal of the present Core is to provide support for other cores and relevant projects of the investigators focused on pharmacokinetic/pharmacodynamic assessments, and to provide relevant instruction for students and area nursing homes, in vivo (phenotyping) and in vitro (drug metabolic assays) studies of cytochrome P450 function, an enzyme responsible for metabolism of significant antidepressants.
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CONTINUATION PHARMACOTHERAPY FOR AGITATION OF DEMENTIA
Continuation Pharmacotherapy for Agitation of Dementia
Geropsychopharmacology: Enhancing Benefit, Reducing Risk
Geropsychopharmacology: Enhancing Benefit, Reducing Risk
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