MECHANISMS OF PAIN AND ANALGESIA

临床上显著的疼痛是由剧烈或长时间的 伤害感受器活性和/或神经损伤。 这些刺激会引发 在某些情况下，周围组织的生理和解剖变化 和中枢神经系统，可以放大和延长活动， 伤害性传入通路并增加疼痛感知。 的统一 该项目的主题是研究延长或 增强组织或神经损伤后的疼痛感。 几 将使用不同的方法。 拉斯顿医生会检查 背角和腹侧丘脑的解剖学重组 周围神经损伤后。 罗博瑟姆博士将研究 在受损的初级传入伤害感受器中的活动的贡献， 带状疱疹后神经痛患者的疼痛传入阻滞。 博士 Levine将研究交感神经系统对原发性和继发性肿瘤的影响， 皮内注射辣椒素引起的继发性痛觉过敏。 巴斯鲍姆博士 将研究脊髓神经元在疼痛传递中的作用， 神经激肽一受体和初级传入终末的表达 NMDA受体，并将使用体内微透析来监测 RVM中GABA的调节。 菲尔兹博士将研究 和脑干神经元的递质含量， 脊柱 伤害性传递 高度互动和凝聚力的团队努力 将通过一个积极合作的计划， 设备和技术以及正式的教学和研究会议。

Clinically significant pains are produced by intense or prolonged nociceptor activity and/or nerve injury. These stimuli initiate physiological and, in some cases, anatomical changes in the peripheral and central nervous system that may amplify and prolong activity in nociceptive afferent pathways and increase pain perception. The unifying theme of this program project is the study of mechanisms that prolong or enhance pain perception following tissue or nerve injury. Several different approaches will be used. Dr. Ralston will examine the anatomical reorganization of the dorsal horn and ventrobasal thalamus following peripheral nerve injury. Dr. Rowbotham will study the contribution of activity in damaged primary afferent nociceptors and deafferentation to pain in patients with post herpetic neuralgia. Dr. Levine will study sympathetic nervous system influences on primary and secondary hyperalgesia induced by intradermal capsaicin. Dr. Basbaum will study the role in pain transmission of spinal neurons bearing the neurokinin one receptor and of primary afferent terminals that express the NMDA receptor and will use in vivo microdialysis to monitor the regulation of GABA in the RVM. Dr. Fields will study the connectivity and transmitter content of brainstem neurons that modulate spinal nociceptive transmission. A highly interactive and cohesive group effort will be fostered through a program of active collaboration, shared equipment and techniques and formal teaching and research conferences.