ROLE FOR HYPOTHALAMIC ADRENERGIC RECEPTORS IN PREOVULATORY LH SURGE

下丘脑肾上腺素能受体在排卵前 LH 激增中的作用

• 批准号: 6247237
• 负责人: HAROLD G SPIES
• 金额: $ 4.86万
• 依托单位: OREGON REGIONAL PRIMATE RESEARCH CENTER
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-05-01 至 1998-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6247237
• 关键词: Mammalia; Primates; biological products; endocrine gland /system; hormones; nervous system; reproductive system; women's health

Coitus induces an increase in hypothalamic norepinephrine (NE) secretion that occurs several minutes prior to a preovulatory-like surge of gonadotropin-releasing hormone (GnRH)/luteinizing hormone (LH). To assess the causal relationship between NE and GnRH/LH release during coitus, we attempted to block the coitus-induced GnRH/LH surge by intrahypothalamic (ih) infusion of an `-adrenergic receptor blocker, prazosin. Intact female rabbits were subjected to push-pull perfusion for 7 h with continuous 10-min sample collections for perfusate GnRH and blood LH measurements. Mating with male partners occurred at the third hour and continuous ih prazosin was given between hours 2 and 7. Present data show that the magnitude of the coitus-induced GnRH/LH release was lower in prazosin-treated females as compared to that in the control group. However, prazosin did not completely abolish the GnRH/LH response to coitus. To this end, at least three interpretations can be offered (1) NE is not the only factor determining the coitus-induced GnRH/LH surge, (2) NE may also stimulate GnRH via `-adrenergic receptors located outside the mediobasal hypothalamus, and (3) the dosage of prazosin may be insufficient to block all `-adrenergic receptors within the mediobasal hypothalamus. We continue to explore these issues. Ultimately, the findings will aid understanding of brain functions during fertile and infertile reproductive stages.

性交诱导下丘脑去甲肾上腺素（NE）升高