131-I LABELED TUMOR-AVID PHOSPHOLIPID ANALOG IN PATIENTS WITH COLON CANCER

结肠癌患者中的 131-I 标记的肿瘤亲和磷脂类似物

• 批准号: 6244577
• 负责人: RICHARD Leo WAHL
• 金额: $ 2.22万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-02-20 至 1997-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6244577
• 关键词: clinical research; colon neoplasms; ethers; human subject; human therapy evaluation; iodine; neoplasm /cancer radionuclide diagnosis; neoplasm /cancer radionuclide therapy; pharmacokinetics; phospholipids; radiation dosage

We will evaluate in patients the in vivo pharmacokinetics, dosimetry and tumor localization properties of 131 I NM-324, a phospholipid ether which accumulates preferentially in cancers. Initial studies are being performed in patients with colorectal cancer to determine whether the extent of targeting is adequate to suggest this agent has either diagnostic or therapeutic potential.

我们将在患者中评价体内药代动力学、剂量测定和 磷脂醚131 I NM-324的肿瘤定位特性 其优先在癌症中积累。 初步研究正在 在结直肠癌患者中进行，以确定 靶向程度足以表明该药剂具有 诊断或治疗潜力。