Imaging, Probes and Biostatistics

成像、探针和生物统计学

• 批准号: 8555372
• 负责人: RICHARD Leo WAHL
• 金额: $ 10.83万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-08-10 至 2016-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8555372
• 关键词: Advanced Malignant Neoplasm; Biometry; Books; Budgets; Cancer Patient; Chairperson; Clinical; Clinical Research; Collagen; Contrast Media; Data; Development; Equipment; Fiber; Funding; Future; Human; Image; Image Analysis; Imaging Techniques; Imaging technology; Individual; Lead; Leadership; Magnetic Resonance Imaging; Malignant Neoplasms; Microscopic; Modality; Nuclear; Online Systems; Play; Positron-Emission Tomography; Quality Control; Radionuclide Imaging; Research; Research Infrastructure; Research Personnel; Research Project Grants; Resources; Role; Services; Site; Spectrum Analysis; Structure; Time; Transgenic Model; Vision; Xenograft procedure; base; career; career development; cost; design; image visualization; imaging modality; imaging probe; in vivo Cellular and Molecular Imaging Centers; meetings; member; molecular imaging; molecular oncology; multimodality; novel; optical imaging; pre-clinical; preclinical study; programs; research and development; research study; single photon emission computed tomography; skills; translational approach

The Imaging and Probes Resource will provide a seamless translational approach that will integrate multimodality MR, PET, SPECT, and optical imaging and probe development to understand and effectively treat cancer. The research studies in this JHU ICMIC application require a wide range of imaging methods and imaging probe development that span the imaging of microscopic structures such as collagen 1 fibers, to preclinical imaging of human cancer xenografts and transgenic models, to imaging cancer patients. This resource will provide the requisite infrastructure and act as a central resource for JHU ICMIC investigators to obtain expertise and assistance for multi-modality imaging, image visualization and analyses, and imaging probe development. This resource will also perform research and development in imaging and probe development in the JHU ICMIC. The resource will play a valuable role in identifying and developing novel imaging technologies and probes as individual research projects evolve within the program. The aims of this resource are to: (i) Guide and assist investigators in the use of imaging technologies, and to identify the most appropriate imaging technology for the research studies, (ii) Develop and provide state-of- the-art image analyses and visualization necessary for multi-modality imaging data, (iii) Identify, develop, and provide novel contrast agents for MR, radionuclide, and optical imaging applications, (iv) Develop agents against critical targets identified during the course of the research programs in the center, (v) Identify the most promising preclinical Imaging techniques and agents for future clinical use. Members of this resource are versatile in imaging and probe development and can function interchangeably in this resource resulting in a commonality of effort.

成像和探头资源将提供一个无缝的翻译方法，将整合多模态 MR、PET、SPECT、光学成像和探头开发，以了解和有效治疗 癌该JHU ICMIC应用的研究需要广泛的成像方法， 成像探针的开发，其跨越了诸如胶原1纤维的微观结构的成像， 人类癌症异种移植物和转基因模型的临床前成像，以成像癌症患者。这 资源将提供必要的基础设施，并作为JHU ICMIC调查人员的中心资源 获得多模态成像、图像可视化和分析的专业知识和帮助，以及 成像探头开发该资源还将进行成像和 探索JHU ICMIC的发展。该资源将在识别和开发 新的成像技术和探针作为个别研究项目的发展在该计划。的 该资源的目的是：（i）指导和协助研究人员使用成像技术，并 确定最合适的成像技术的研究，（二）开发和提供国家的- 多模态成像数据所需的最先进的图像分析和可视化，（iii）识别， 开发并提供用于MR、放射性核素和光学成像应用的新型造影剂，（iv） 针对中心研究计划过程中确定的关键目标开发代理人， (v)确定最有前途的临床前成像技术和试剂，以供未来临床使用。成员 这些资源在成像和探针开发中是通用的，并且可以在这方面互换使用。 资源导致共同的努力。