SIGNAL TRANSDUCTION BY G PROTEINS IN THE RETINAL PIGMENT EPITHELIUM

视网膜色素上皮中 G 蛋白的信号转导

• 批准号: 6244636
• 负责人: DEBRA A THOMPSON
• 金额: $ 2.22万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-02-20 至 1997-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6244636
• 关键词: G protein; biological signal transduction; neurons; receptor expression; retina; retinal pigment epithelium; tissue /cell culture

Our laboratory is interested in the molecular study of the biochemical events that underlie the coordinate physiology of the neural retina and retinal pigment epithelium (RPE). Our focus is on cellular responses in the RPE mediated by Guanine nucleotide binding proteins (G-Proteins). We are attempting to identify RPE specific G-Proteins and G protein- coupled receptors based on their predicted homology with similar proteins from other tissues.

我们的实验室对生物化学的分子研究很感兴趣 神经视网膜协调生理学的基础事件， 视网膜色素上皮（RPE）。 我们的重点是细胞反应 由鸟嘌呤核苷酸结合蛋白（G蛋白）介导的RPE。 我们正在尝试识别RPE特异性G蛋白和G蛋白- 偶联受体的基础上预测的同源性与类似的 其他组织的蛋白质。