课题基金 / 基金详情

MALIC ACID THERAPY FOR SUSPECTED FUMARASE DEFICIENCY

苹果酸治疗疑似富马酸酶缺乏症

批准号：

2478603

负责人：

金额：

$2.21万

依托单位：

UNIVERSITY OF MICHIGAN AT ANN ARBOR

依托单位国家：

美国

项目类别：

财政年份：

资助国家：

美国

项目状态：

未结题

起止时间：

至

来源：

https://reporter.nih.gov/project-details/2478603

关键词：

Krebs' cycle clinical research human subject human therapy evaluation malates

项目摘要

项目成果

相似基金

相关文献

中文摘要

翻译

点击翻译按钮获取中文摘要

英文摘要

Malic acid is widely distributed in nature comprising up to almost 1% by weight of the content of apples. In mammals it is formed in the penultimate reaction in the Krebs cycle and after conversion to oxaloacetate. Malic acid is absorbed by the gut and has specific plasma membrane transporters. This protocol investigates whether provision of malic acid to patients with defects in the Krebs cycle will lead to clinical improvement. One infant has been treated at this time.

期刊论文(0)

专著(0)

科研奖励(0)

会议论文