MORPHINE KINETICS AND DYNAMICS--EFFECT OF ADMINISTRATION ROUTE

吗啡动力学和动力学--给药途径的影响

• 批准号: 6245075
• 负责人: KIM BROUWER
• 金额: $ 1.34万
• 依托单位: UNIV OF NORTH CAROLINA CHAPEL HILL
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-01-06 至 1997-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6245075
• 关键词: biotransformation; clinical research; dosage; drug administration routes; drug metabolism; gastrointestinal pharmacology; human data; liver metabolism; morphine; pharmacokinetics

Results of this study will provide sufficient information to determine the fractional contribution of gastrointestinal and hepatic biotransformation to the overall presystemic elimination or morphine which will improve our understanting of the in vivo diodisposition of morphine. A comprehensive pharmacokinetic-pharmacodynamic model for morphine and the metabolites, M3G and M6G, will be developed. This model will be sued to determine equi-analgesic doses of morphine adfministred by various routes.

本研究的结果将提供足够的信息来确定 胃肠道和肝脏的贡献分数 生物转化为整体系统前消除或吗啡 这将有助于我们了解体内的 吗啡 一个全面的药代动力学-药效学模型， 吗啡及其代谢产物M3 G和M6 G将被开发出来。 这 模型将被用来确定等效镇痛剂量的吗啡 通过不同的路线进行管理。