TREATMENT OF HEMISPATIAL NEGLECT WITH DOPAMINERGIC AGONISTS

用多巴胺能激动剂治疗半侧空间忽视

• 批准号: 6245193
• 负责人: ZORAN GRUJIC
• 金额: $ 1.2万
• 依托单位: NORTHWESTERN UNIVERSITY AT CHICAGO
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-07-15 至 1997-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6245193
• 关键词: attention; brain interhemispheric activity; bromocriptine; cardiovascular disorder chemotherapy; chronic brain damage; clinical research; dopamine agonists; human subject; human therapy evaluation; stroke; syndrome

The syndrome of hemispatial neglect has been associated with impaired functional rehabilitation of patients with right hemisphere damage. Even though there is evidence in the animal literature to support the role of dopamine in the control of attention and neglect, there have been only a few studies evaluating pharmacologic intervention in the human neglect syndrome. The overall aim of this project is to learn whether patients with hemispatial neglect would benefit from dopamine agonist therapy. In particular, we propose to treat (with bromocriptine) patients with strokes involving the right striatum. We will exmaine which if any of the behavioral components of directed attention (exploratory-motor or sensory-representational) improve.

偏侧空间忽视综合症与受损有关 右脑损害患者的功能康复。连 尽管在动物文献中有证据支持 多巴胺在控制注意力和忽视方面，已经只有 评价药物干预对人类忽视的几项研究 综合症。该项目的总体目标是了解患者是否 有偏侧空间忽视的患者将受益于多巴胺激动剂治疗。 特别是，我们建议(用溴隐亭)治疗 涉及右侧纹状体的中风。我们将解释，如果有的话， 定向注意的行为成分(探索性运动或 感官-表象)提高。