TREATMENT OF HEMISPATIAL NEGLECT WITH DOPAMINERGIC AGONISTS

用多巴胺能激动剂治疗半侧空间忽视

• 批准号: 6114068
• 负责人: ZORAN GRUJIC
• 金额: $ 2.37万
• 依托单位: NORTHWESTERN UNIVERSITY AT CHICAGO
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/6114068
• 关键词: attention; brain interhemispheric activity; bromocriptine; cardiovascular disorder chemotherapy; chronic brain damage; clinical research; dopamine agonists; human subject; human therapy evaluation; stroke; syndrome

The syndrome of hemispatial neglect has been associated with impaired functional rehabilitation of patients with right hemisphere damage. Even though there is evidence in the animal literature to support the role of dopamine in the control of attention and neglect, there have been only a few studies evaluating pharmacologic intervention in the human neglect syndrome. The overall aim of this project is to learn whether patients with hemispatial neglect would benefit from dopamine agonist therapy. In particular, we propose to treat (with bromocriptine) patients with strokes involving the right striatum. We will examine which if any of the behavioral components of directed attention (exploratory-motor or sensory- representational) improve.

半脑半球忽视综合征与脑功能受损有关