课题基金 / 基金详情

PHARMACOKINETICS/DYNAMICS OF COMBINED KETOCONAZOLE/TRIAZOLAM/ALPRAZOLAM

PHARMACOKINETICS/DYNAMICS OF COMBINED KETOCONAZOLE/TRIAZOLAM/ALPRAZOLAM
复方酮康唑/三唑仑/阿普唑仑的药代动力学/动力学
批准号：
6245518
负责人：
DAVID J GREENBLATT
金额：
$2.82万
依托单位：
TUFTS MEDICAL CENTER
依托单位国家：
美国
项目类别：
财政年份：
1997
资助国家：
美国
项目状态：
已结题
起止时间：
1997-05-01 至 1997-11-30
来源：
https://reporter.nih.gov/project-details/6245518
关键词：
alprazolam clinical research drug interactions human subject ketoconazole pharmacokinetics triazolam

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中文摘要
翻译
人肝微粒体制剂的体外研究
英文摘要
In vitro studies of human liver microsomal preparations done in our laboratory identify the antifungal agent ketoconazole as a potent inhibitor of cytochrome P450-3A4, the enzyme responsible for biotransformation of the benzodiazepines triazolam and alprazolam in humans. In vitro data predicts a clinically important pharmacokinetic interaction of ketoconazole with triazolam and alprazolam in humans, much as has been reported during concurrent treatment of ketoconazole with terfenadine (seldane). The present study is a controlled evaluation of the potential interaction of ketoconazole with triazolam and with alprazolam, including the clinical consequences of the interaction.
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