VITAMIN A AND E MAY INCREASE RETINOPATHY IN PREMATURE INFANTS

维生素 A 和 E 可能会增加早产儿视网膜病变

• 批准号: 6245322
• 负责人: Christine A Gleason
• 金额: $ 2.23万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-03-05 至 1997-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6245322
• 关键词: blood chemistry; clinical research; disease /disorder proneness /risk; drug adverse effect; human subject; infant human (0-1 year); longitudinal human study; photosensitizing agents; porphyrins; premature infant human; retinoids; retinopathy of prematurity; tocopherols; vitamin therapy

The primary objective of our clinical research study is to determine whether some premature babies are at higher risk of developing retinopathy of prematurity (ROP) because they have elevated levels of protoporphyrin IX, a photosensitizer, along with low levels of Vitamin A and E. If we could determine (at birth) which babies are at highest risk, we could develop preventative strategies targeted specifically to them. During this past study period, we discovered a previously unrecognized technical difficulty with one of the blood tests wer are performing. While we are investigating this problem and searching for alternatives, we have suspended enrollment of patients in the study.

我们临床研究的主要目的是确定 是否有些早产儿患视网膜病变的风险更高 早产儿（ROP），因为他们有原卟啉水平升高 IX，光敏剂，沿着低水平的维生素A和E。 如果我们 可以确定（在出生时）哪些婴儿处于最高风险，我们可以 制定专门针对他们的预防战略。 在过去的研究期间，我们发现了一种以前未被发现的 我们正在进行的一项血液测试出现了技术困难。 当我们调查这个问题并寻找替代方案时，我们 已经暂停了患者的入组