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ADMINISTRATION OF NORMAL CDNA ADENOVIRUS VECTOR IN CYSTIC FIBROSIS

ADMINISTRATION OF NORMAL CDNA ADENOVIRUS VECTOR IN CYSTIC FIBROSIS
正常 CDNA 腺病毒载体在囊性纤维化中的施用
批准号：
6245118
负责人：
RONALD G CRYSTAL
金额：
$5.36万
依托单位：
WEILL MEDICAL COLL OF CORNELL UNIV
依托单位国家：
美国
项目类别：
财政年份：
1997
资助国家：
美国
项目状态：
已结题
起止时间：
1997-02-24 至 1997-11-30
来源：
https://reporter.nih.gov/project-details/6245118
关键词：
Adenoviridae clinical research complementary DNA cystic fibrosis drug administration routes gene expression gene therapy genetic enhancer element genetic promoter element human subject human therapy evaluation pharmacogenetics pharmacokinetics recombinant virus respiratory epithelium transfection /expression vector

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英文摘要
This protocol will evaluate the safety and biologic efficacy of repeat administration of the recombinant adenovirus vector AdgvCFTR.10 to the airway epithelium of individuals with cystic fibrosis. Key elements of this study are: administration of the vector to more localized areas of the airways, more careful definition of the pharmacodynamics of expression of the normal CFTR cDNA, evaluation of this expression following repeat administration, and use of a more active promoter/enhancer in the expression cassette.
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  • 批准号：
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  • 项目类别：
  • 资助金额：
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  • 财政年份：
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  • 负责人：
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  • 依托单位：
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