NICOTINE ON SENSORY GATING OF AUDITORY EVOKED POTENTIALS IN MAN

患者将在两个不同的地方接受一天的治疗 在某些场合。患者将在实验当天早上住进非营利组织。 静脉注射将从生理盐水开始，定期的血液样本将从 在白天较晚的时间点拍摄。这位病人将被给予 在治疗方案开始前由阿德勒医生进行体检。这个 病人在静脉注射后安静地躺30分钟，然后 进行体检。然后病人就会被唤醒 然后记录电势。然后病人将接受神经生理学检查。 由调查小组进行的测试。然后病人就会被 给予尼古丁口香糖或安慰剂咀嚼5分钟，然后吐出 出去。如果患者是不吸烟的，正常对照没有服用抗精神病药物 药物治疗前，他们将被给予60毫克-90毫克的丙氨酸 用安慰剂或尼古丁口香糖治疗。10分钟、60分钟和 120分钟的周期，诱发电位记录，神经心理学测试和 鲜血将会重演。

Patients will be admitted to the CRC for one day on two separate occasions. Patients will be admitted NPO in he morning of the experiment. An IV will be started with saline from which periodic blood samples will be taken at later time points during the day. The patient will be giv en a physical examination by Dr. Adler before the protocol is started. The patient will lie quietly for 30 minutes after the IV is put in and physical exam is administered. The patient will then have her evoked potentials are then recorded. The patient will then have neurophyscology tests administered by the investigative team. The patient will then be given either nicotine gum or placebo to chew for 5 minutes and then spit out. If the patient is a non smoking normal control not on neuroleptic medication, they will be given 60 mg-90 mg of propanthaline prior to treatment with either placebo or nicotine gum. 10 minute, 60 minute and 120 minute periods, evoked potential recording, neuropsychology tests and blood will be repeated.