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PHASE I TRIAL AND PHARMACOKINETIC STUDY OF CARMUSTINE AND TEMOZOLOMIDE

PHASE I TRIAL AND PHARMACOKINETIC STUDY OF CARMUSTINE AND TEMOZOLOMIDE
卡莫司汀和替莫唑胺的 I 期试验和药代动力学研究
批准号：
6245680
负责人：
MICHAEL BOZIK
金额：
$1.76万
依托单位：
UNIVERSITY OF PITTSBURGH AT PITTSBURGH
依托单位国家：
美国
项目类别：
财政年份：
1997
资助国家：
美国
项目状态：
已结题
起止时间：
1997-03-18 至 1997-11-30
来源：
https://reporter.nih.gov/project-details/6245680
关键词：
antineoplastics carmustine central nervous system neoplasms clinical research clinical trial phase I human subject human therapy evaluation neoplasm /cancer chemotherapy pharmacokinetics

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英文摘要
This is a phase I pharmacokinetic (PK) study of carmustine (BCNU) & temozolomide in patients with CNS tumors. It is anticipated that 10 patients will enter this study at the UPCI. PK will be performed during the first cycle of therapy of both arms of the study at all dose levels. The primary endpoint of the study will be determination of the MTD of temozolomide plus BCNU for each schedule.
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PHASE I TRIAL AND PHARMACOKINETIC STUDY OF CARMUSTINE AND TEMOZOLOMIDE
PHASE I/II STUDY OF PACLITAXEL CHEMOTHERAPY IN RECURRENT MALIGNANT GLIOMA
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