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STUDY OF THE SEQUENTIAL ADMINISTRATION OF CARMUSTINE AND TEMOZOLOMIDE

STUDY OF THE SEQUENTIAL ADMINISTRATION OF CARMUSTINE AND TEMOZOLOMIDE
卡莫司汀和替莫唑胺序贯给药的研究
批准号：
6276457
负责人：
MICHAEL D PRADOS
金额：
$6.43万
依托单位：
UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
依托单位国家：
美国
项目类别：
财政年份：
1997
资助国家：
美国
项目状态：
已结题
起止时间：
1997-12-01 至 1999-11-30
来源：
https://reporter.nih.gov/project-details/6276457
关键词：
antineoplastics blood chemistry carmustine clinical research clinical trial phase I drug administration rate /duration drug adverse effect drug interactions drug screening /evaluation human subject human therapy evaluation neoplasm /cancer chemotherapy pharmacokinetics

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中文摘要
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英文摘要
This Phase I trial and pharmacokinetic study is to describe Temozolomide given orally on day 1 of each 6-week schedule with BCNU given either before or after the Temozolomide. To describe the different toxicities, activity and change in Temozolomide pharmacokinetics for each schedule. The GCRC will administer BCNU/ Temozolomide, draw blook for pharmacokinetic studies, do line-care teaching as needed.
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