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HOMOCYSTEINE AND ENDOTHELIAL FUNCTION IN HUMANS

HOMOCYSTEINE AND ENDOTHELIAL FUNCTION IN HUMANS
同型半胱氨酸和人类内皮功能
批准号:
6245880
负责人:
ALLYN L. MARK
金额:
$1.92万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
1997
资助国家:
美国
项目状态:
已结题
起止时间:
1997-02-01 至 1997-11-30

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中文摘要
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英文摘要
The hypothesis of this study is that moderate hyperhomocysteinemia causes endothelial dysfunction in humans. We will examine subjects with and without conventional risk factors for atherosclerosis in order to assess whether moderate hyperhomocysteinemia has deleterious endothelial effects alone or only in combination with other risk factors known to impair endothelial function. Endothelial function will be tested in conduit vessels using flow mediated vasodilatation and in resistance vessels using brachial artery administration of drugs to cause endothelium- dependent vasodilatation and to inhibit generation of nitric oxide.
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会议论文
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海外基金