COMMUNITY COMPONENT--PERFORMANCE LIMITATIONS IN RHEUMATOID ARTHRITIS PATIENT

本提案继续对类风湿性关节炎（RA）的队列研究 在一项全国性的研究中， 类风湿关节炎 这项建议是建立在以下原则之上的： 开发更有意义的关节炎健康结果指标 患者的社会角色功能。 几个重要结果 已经来自这项研究。 就业状况的重要性 抑郁症已经显示;一个有效和可靠的社会措施， 开发了支持，并用于其他关节炎研究; 家庭和有偿工作角色以及影响功能状态的因素 在家庭工作中的作用得到了评估。 这些家庭角色指标是 也被用于其他研究项目。 最后，功能 治疗患者中类风湿关节炎的下降是一个漫长的过程 需要额外的研究年来可靠地调查这些 延迟功能丧失的关键因素。 这项研究是独一无二的， 提供了一个异常广泛的关节炎样本的数据 从美国各地的风湿病学实践中随机抽取的患者 States. 该研究将继续跟踪820人的样本， 类风湿性关节炎，以：1）描述的过程中的变化， 类风湿关节炎患者的社会角色功能; 2） 分析结构、临床和背景因素对 保持功能状态和社会功能的能力; 3）提高 我们对角色自主性的测量的敏感性和特异性， 角色要求。 电话采访将用于收集自我- 报告的社会人口学特征、症状、身体状况 社会角色功能和情绪状态。 医生 将报告临床疾病状态的数据。 分析战略将 包括重复测量设计MANOVA，对数线性技术， 分类依赖测量和比例风险生存情况 在这些情况下，可以评估达到结果的时间。

This proposal continues a study on a cohort of rheumatoid arthritis (RA) patients in A National Study of Role Limitations among Patients with Rheumatoid Arthritis. The proposal is founded on the principle of developing more meaningful indicators of health outcomes in arthritis patients based on social role functioning. Several important results have already come from this study. the importance of employment status on depression has been shown; a valid and reliable measure of social support was developed and is being used in other arthritis studies; family and paid work roles and factors contributing to functional status in family work have been assessed. These family role indicators are being used in other research projects, as well. Finally, functional decline in RA among treated patients is a long and protracted process requiring additional years of study to reliably investigate those factors critical in delaying functional losses. This study is unique in providing NATIONAL data on an unusually broad sample of arthritis patients drawn randomly from rheumatology practices across the United States. The study will continue to follow a sample of 820 people with rheumatoid arthritis in order to: 1) describe the course of change in social role functioning among patients with rheumatoid arthritis; 2) analyze the effects of structural, clinical and contextual factors on ability to maintain functional status and social function; 3) improve the sensitivity and specificity of our measures of role autonomy and role demands. Telephone interviews will be used to collect self- reported data on sociodemographic characteristics, symptoms, physical functioning, social role functioning and emotional state. Physicians will report data on clinical disease status. Analytical strategies will include repeated measures design MANOVA, loglinear techniques in the case of categorical dependent measures and proportional hazards survival models in those cases where time to outcome can be assessed.