MULTIPURPOSE ARTHRITIS & MUSCULOSKELETAL DISEASES CENTER

多用途关节炎

• 批准号: 2442803
• 负责人: STEPHEN A PAGET
• 金额: $ 98.27万
• 依托单位: HOSPITAL FOR SPECIAL SURGERY
• 依托单位国家: 美国
• 财政年份: 1988
• 资助国家: 美国
• 起止时间: 1988-07-01 至 1999-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2442803
• 关键词: musculoskeletal disorder; rheumatoid arthritis

The Cornell-Hospital for Special Surgery Multipurpose Arthritis and Musculoskeletal Disease Center (MAMDC) has grown into a mature and highly sophisticated multidisciplinary research effort dedicated to improving our understanding and treatment of musculoskeletal diseases. The long-term objectives of the MAMDC include: 1) to support excellence in laboratory, clinical, behavioral and health services research related to musculoskeletal diseases; 2) to provide training in state-of-the-art methodology in research which can be applied to important questions in both orthopedics and rheumatology; 3) to develop a critical mass of experienced orthopedic, rheumatology, anesthesiology, and arthritis health investigators who can serve as role models and mentors for young new investigators; 4) to develop new educational programs and technologies designed to meet emerging needs in professional, patient and community education; 5) to serve as a research resource in the Cornell University Medical Center (CUMC) and to draw attention and effort to critical problems in musculoskeletal disease. The long-term objectives of the MAMDC will be realized through a series of specific, coordinated efforts. It will provide an important stimulus for young orthopedic (Haas, Deland), rheumatic disease (Ashany, Porges, Ivashkiv), and anesthesiology (Richman) investigators. It will support scientific innovation and the development of new and promising directions of inquiry through focused feasibility studies investigating problems related to: transgenic models of osteocalcin deficiency, the analysis of B cell progenitors in autoimmune mice, the effect of mechanical load on solute transport in tendon fibroblasts, monocyte gene activation in inflammatory arthritis, the definition of the role of Fcgamma receptors in antineutrophil cytoplasmic antibody-mediated cellular activation. Employing state-of-the-art concepts in health services, clinical epidemiology, health education and behavioral sciences, the MAMDC will assess, in randomized trials, the effectiveness and cost of arthroscopic debridement vs. tidal lavage for the treatment of mild-moderate osteoarthritis, the efficacy of epidural steroids vs. epidural analgesia for relief of pain and disability due to spinal stenosis, the effectiveness of orthotics for the treatment of heel pain, and trial of self-efficacy in rehabilitation of hip fracture patients. Serving as a pivotal research and educational resource to MAMDC investigators and to the CUMC community, the MAMDC will provide five critical Core facilities in Flow Cytometry and Cell Sorting, Cell culture, Molecular Biology, Analytical Microscopy, and Research Methodology. Such Core facilities can provide an integration and cohesion which touches all aspects of the medical center. Thus, the MAMDC at Cornell reflects an ongoing, strong commitment to advance scientific and educational innovation as it relates to patients with rheumatic diseases and orthopedic disorders.

康奈尔特殊外科医院多功能关节炎和 肌肉骨骼疾病中心（MAMDC）已发展成为一个成熟和高度 先进的多学科研究工作，致力于提高 我们对肌肉骨骼疾病的理解和治疗。 MAMDC的长期目标包括：1）支持卓越 在实验室，临床，行为和健康服务研究相关 2）提供最先进的培训， 研究方法，可应用于重要问题， 骨科和风湿病学; 3）发展一个临界质量， 经验丰富的骨科，风湿病学，麻醉学和关节炎 健康调查员，他们可以成为年轻人的榜样和导师 新的研究人员; 4）开发新的教育计划， 技术旨在满足专业、患者和 社区教育; 5）作为康奈尔大学的研究资源 大学医学中心（CMEC），并提请注意和努力， 肌肉骨骼疾病的关键问题。 MAMDC的长期目标将通过一系列 具体的、协调的努力。 它将提供重要的刺激 用于年轻的整形外科（哈斯，Deland），风湿性疾病（Ashany，Porges， Ivashkiv）和麻醉学（Richman）研究人员。 它将支持 科学创新和发展新的和有前途的方向 通过重点可行性研究调查问题， 骨钙素缺乏的转基因模型，分析 自身免疫小鼠中B祖细胞，机械负荷的影响 对肌腱成纤维细胞溶质转运的影响， 炎症性关节炎，Fc γ受体作用的定义 在抗神经炎细胞质抗体介导的细胞活化中。 采用最先进的概念，在卫生服务，临床 流行病学，健康教育和行为科学，MAMDC将 在随机试验中评估关节镜手术的有效性和成本， 清创术与潮式灌洗术治疗轻中度 骨关节炎，硬膜外类固醇与硬膜外镇痛的疗效 为减轻因椎管狭窄引起的疼痛和残疾， 矫形器治疗足跟痛的有效性，以及 自我效能感在髋部骨折患者康复中的作用 作为MAMDC的关键研究和教育资源 调查人员和社区，MAMDC将提供五个 流式细胞术和细胞分选的关键核心设施，细胞 培养、分子生物学、分析显微镜和研究 方法论 这些核心设施可以提供一个集成， 凝聚力涉及医疗中心的各个方面。 因此，康奈尔大学的MAMDC反映了一个持续的，坚定的承诺， 推进与患者相关的科学和教育创新 风湿性疾病和骨科疾病。

项目成果

Glucocorticoid therapy for rheumatic diseases.

糖皮质激素治疗风湿性疾病。

• DOI: 10.1097/00002281-199206000-00007
• 发表时间: 1992
• 期刊: Current opinion in rheumatology
• 影响因子: 5.1
• 作者: Kimberly,RP

Nitric oxide: An important articular free radical

• DOI: 10.2106/00004623-199602000-00014
• 发表时间: 1996-02-01
• 期刊: JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME
• 影响因子: 5.3
• 作者: Murrell, GAC;Dolan, MM;Hannafin, JA
• 通讯作者: Hannafin, JA

Anti-neutrophil cytoplasmic antibodies engage and activate human neutrophils via Fc gamma RIIa.

• DOI: 10.4049/jimmunol.153.3.1271
• 发表时间: 1994-08
• 期刊: Journal of immunology
• 影响因子: 4.4
• 作者: A. Porges;P. Redecha;W. Kimberly;Elena Csernok;W. Gross;R. Kimberly

Effect of a walking program on gait characteristics in patients with osteoarthritis.

• DOI: 10.1002/art.1790060104
• 发表时间: 1993-03-01
• 期刊: Arthritis care and research : the official journal of the Arthritis Health Professions Association
• 作者: Peterson, M G;Kovar-Toledano, P A;Kroll, M A
• 通讯作者: Kroll, M A

Hip fracture in older persons. Does self-efficacy-based intervention have a role in rehabilitation?

老年人髋部骨折。

• DOI: 10.1002/art.1790040108
• 发表时间: 1991
• 期刊: Arthritis care and research : the official journal of the Arthritis Health Professions Association
• 作者: Allegrante,JP;MacKenzie,CR;Robbins,L;Cornell,CN
• 通讯作者: Cornell,CN