Discovery and Characterisation of Novel Tick Evasins as Inhibitors of Chemokine-mediated Inflammation

作为趋化因子介导的炎症抑制剂的新型蜱虫逃逸素的发现和表征

• 批准号: nhmrc : 1140867
• 负责人: A/Pr Martin Stone
• 金额: $ 44.28万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2018
• 资助国家: 澳大利亚
• 起止时间: 2018-01-01 至 2020-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/discovery-characterisation-novel-mediated-inflammation/1319329
• 关键词: Discovery; Characterisation; Novel; Tick; Evasins

An important aspect of inflammatory diseases is the migration of white blood cells into the affected tissues. This is controlled by a group of proteins called chemokines. Ticks, which live on mammalian hosts, produce proteins called evasins, which interact with host chemokines and thereby prevent inflammatory responses. This project will discover new tick evasins, study their chemokine interactions and investigate their ability to block inflammation in allergic asthma.

炎症性疾病的一个重要方面是白细胞迁移到受影响的组织中。这是由一组称为趋化因子的蛋白质控制的。扁虱生活在哺乳动物的宿主上，会产生一种名为EVASIN的蛋白质，这种蛋白质会与宿主的趋化因子相互作用，从而防止炎症反应。该项目将发现新的扁虱EVASIN，研究它们的趋化因子相互作用，并研究它们在过敏性哮喘中阻断炎症的能力。