Discovery and Characterisation of Novel Tick Evasins as Inhibitors of Chemokine-mediated Inflammation

炎性疾病的一个重要方面是白色血细胞迁移到受影响的组织中。这是由一组称为趋化因子的蛋白质控制的。生活在哺乳动物宿主上的蜱产生一种称为evasins的蛋白质，这种蛋白质与宿主趋化因子相互作用，从而防止炎症反应。该项目将发现新的蜱evasins，研究它们与趋化因子的相互作用，并研究它们阻断过敏性哮喘炎症的能力。

An important aspect of inflammatory diseases is the migration of white blood cells into the affected tissues. This is controlled by a group of proteins called chemokines. Ticks, which live on mammalian hosts, produce proteins called evasins, which interact with host chemokines and thereby prevent inflammatory responses. This project will discover new tick evasins, study their chemokine interactions and investigate their ability to block inflammation in allergic asthma.