Mechanisms of Ligand-Selective Signalling by Chemokine Receptors

趋化因子受体的配体选择性信号传导机制

• 批准号: nhmrc : 1140874
• 负责人: A/Pr Martin Stone
• 金额: $ 50.67万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2018
• 资助国家: 澳大利亚
• 起止时间: 2018-01-01 至 2020-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/mechanisms-ligand-selective-chemokine-receptors/1319332
• 关键词: Mechanisms; Ligand; Selective; Signalling; Chemokine

Receptors are molecules located on the surfaces of cells. They control the response of one cell to chemical signals emitted by different cells. In this project we aim to characterise and understand the molecular details of how a receptor can respond differently to distinct chemical signals. The results of this study will help to guide future development of medicines to control white blood cell migration into tissues during inflammatory diseases such as heart disease, diabetes and arthritis.

受体是位于细胞表面的分子。它们控制一个细胞对不同细胞发出的化学信号的反应。在这个项目中，我们的目标是研究和理解受体如何对不同的化学信号做出不同反应的分子细节。这项研究的结果将有助于指导未来药物的开发，以控制心脏病、糖尿病和关节炎等炎症性疾病期间白色血细胞迁移到组织中。