Droplet microfluidic based sensors for high resolution chemical sensing on autonomous underwater vehicles

基于液滴微流体的传感器,用于自主水下航行器的高分辨率化学传感

基本信息

  • 批准号:
    NE/R013578/1
  • 负责人:
  • 金额:
    $ 41.77万
  • 依托单位:
  • 依托单位国家:
    英国
  • 项目类别:
    Fellowship
  • 财政年份:
    2018
  • 资助国家:
    英国
  • 起止时间:
    2018 至 无数据
  • 项目状态:
    已结题

项目摘要

Chemical processes within the oceans underpin the planet's natural cycles of life. Marine ecology, for example, depends on where and in what quantity nutrients (such as nitrate and phosphate) are transported, as these constitute the ultimate base of the food chain. The oceans are also in dynamic equilibrium with the atmosphere and are intrinsic to how the world will adjust to the effects of anthropogenic carbon dioxide. Thus better understanding of oceanic chemical dynamics is not only of academic interest, but will also lead to better protection of marine life and improved models to understand and predict climatic change.To properly understand ocean chemistry, however, we must be able to accurately measure the temporal and spatial distributions of chemical species within the environment and how they change in response to different stimuli. The vastness of the oceans provides a logistical problem however - how can we possibly characterise such a large and complex body of water? One compelling answer to this is to employ autonomous underwater vehicles (AUVs) equipped with chemical sensors. AUVs can travel to remote locations for months at a time without need of human interaction and as such offer a highly efficient way to gather information about the chemical dynamics of the ocean.The current state-of-the-art chemical sensors (which automatically sample and analyse the water using miniaturised laboratory assays) provide superlative analytical performance (accuracy, precision, sensitivity) but suffer from inefficient use of resources (power, fluid) and low measurement frequencies - limiting their applicability to AUVs. In response to this, during this fellowship I will develop a new type of chemical sensor based around droplet microfluidics. Droplet microfluidics involves the generation, manipulation and measurement of discrete droplets of water dispersed within a stream of oil flowing along tubing hundreds of microns in width. As the droplet volumes are so small (sub-microlitre), chemical treatments and measurements can be quickly and precisely performed, meaning droplet microfluidics offers a rapid and highly efficient route to continuous sampling and chemical analysis of the environment.While droplet microfluidics is a proven and widely used tool for laboratory-based analytical chemistry, it is only now making its way into the first field-deployable devices. In this fellowship I will drive improvements in the sensitivity, measurement frequency and applicability of field-deployable droplet microfluidics to develop droplet microfluidic sensors suitable for use on AUVs. The sensors will be highly efficient (low power and fluid use), capable of measuring several different chemical parameters with high sensitivity (meaning they can be used in a wide range of marine environments) and at high measurement frequencies (which translates into richly detailed spatial data when used on moving vehicles). This project will be a key step towards the widespread, routine usage of sensors to monitor chemical change in the marine environment, in particular on AUVs. It will lead to chemical sensors being a ubiquitous tool in environmental science in the future, eventually deployed in large volumes throughout the oceans on static moorings and ocean-going autonomous vehicles.
海洋中的化学过程支撑着地球的自然生命周期。例如,海洋生态取决于营养物质(如硝酸盐和磷酸盐)被运输到哪里以及运输的数量,因为这些营养物质构成了食物链的最终基础。海洋与大气也处于动态平衡状态,是世界如何适应人为二氧化碳影响的内在因素。因此,更好地了解海洋化学动力学不仅具有学术意义,而且将有助于更好地保护海洋生物,改进了解和预测气候变化的模型。然而,要正确理解海洋化学,我们必须能够准确地测量环境中化学物种的时空分布及其对不同刺激的响应。然而,浩瀚的海洋带来了一个后勤问题--我们怎么可能描述这样一个巨大而复杂的水体?一个令人信服的解决方案是使用配备了化学传感器的自动水下机器人(AUV)。AUV一次可以在不需要人类交互的情况下旅行数月,因此提供了一种高效的方式来收集有关海洋化学动力学的信息。目前最先进的化学传感器(使用微型实验室分析自动采样和分析水)提供了最高的分析性能(精确度、精密度和灵敏度),但存在资源(电力、流体)使用效率低和测量频率低的问题-限制了它们对AUV的适用性。针对这一点,在本次联谊会期间,我将开发一种基于液滴微流体的新型化学传感器。液滴微流体学涉及产生、操作和测量分散在沿数百微米宽的油管流动的油流中的离散水滴。由于液滴体积很小(亚微升),可以快速准确地进行化学处理和测量,这意味着液滴微流体为环境的连续采样和化学分析提供了一种快速高效的途径。虽然液滴微流体是实验室分析化学的一种经过验证和广泛使用的工具,但它现在才刚刚进入第一批可现场部署的设备。在这项研究中,我将推动改进现场可展开液滴微流体的灵敏度、测量频率和适用性,以开发适用于AUV的液滴微流体传感器。传感器将是高效率的(低功耗和低液体使用),能够以高灵敏度测量几种不同的化学参数(这意味着它们可以在广泛的海洋环境中使用),并在高测量频率下(在移动的车辆上使用时,这将转化为丰富详细的空间数据)。该项目将是朝着广泛、常规地使用传感器监测海洋环境中的化学变化,特别是在自动潜航器上的关键一步。这将导致化学传感器在未来成为环境科学中无处不在的工具,最终在静态系泊和远洋自动驾驶车辆上大量部署在整个海洋中。

项目成果

期刊论文数量(10)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
A droplet microfluidic-based sensor for monitoring river nitrate/nitrite concentrations
用于监测河流硝酸盐/亚硝酸盐浓度的基于液滴微流体的传感器
AN IN SITU DROPLET MICROFLUIDICS BASED AMMONIUM SENSOR AND ITS APPLICATION TO A SEQUENTIAL BATCH BIOREACTOR
基于原位液滴微流控的铵传感器及其在序批式生物反应器中的应用
Sensitive absorbance measurement in droplet microfluidics via multipass flow cells
通过多通道流通池对液滴微流体进行灵敏的吸光度测量
  • DOI:
    10.29363/nanoge.eimc.2021.021
  • 发表时间:
    2021
  • 期刊:
  • 影响因子:
    0
  • 作者:
    Lu B
  • 通讯作者:
    Lu B
3D printed filtration and separation devices with integrated membranes and no post-printing assembly
3D打印过滤和分离装置,带有集成膜,无需打印后组装
Easily-fabricated fluoropolymer chips for sensitive long-term absorbance measurement in droplet microfluidics
易于制造的含氟聚合物芯片,用于液滴微流体中灵敏的长期吸光度测量
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Adrian Nightingale其他文献

Aeromedical retrieval for suspected preterm labour or rupture of membranes in the Northern Territory, Australia: may some cases be safely not retrieved?
  • DOI:
    10.1186/s12884-024-07013-w
  • 发表时间:
    2024-11-30
  • 期刊:
  • 影响因子:
    2.700
  • 作者:
    Annie Langston-Cox;Emily Warton;Nadine Tipping;Harrison L. Odgers;Adrian Nightingale;Sherihan Goni;Jane Thorn;Kiarna Brown;Holger W. Unger
  • 通讯作者:
    Holger W. Unger

Adrian Nightingale的其他文献

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