NK RECEPTOR FOR HLA CLASS I IN MARROW TRANSPLANTATION
骨髓移植中 HLA I 类的 NK 受体
基本信息
- 批准号:6203038
- 负责人:
- 金额:$ 24.52万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:1999
- 资助国家:美国
- 起止时间:1999-08-24 至 2000-07-31
- 项目状态:已结题
- 来源:
- 关键词:MHC class I antigen bone marrow transplantation cell type clinical research family genetics genetic mapping genotype graft versus host disease histocompatibility homologous transplantation human subject leukemia lymphocyte proliferation minimal residual disease molecular cloning natural killer cells neoplasm /cancer immunology neoplasm /cancer relapse /recurrence nucleic acid sequence polymerase chain reaction receptor expression southern blotting transplantation immunology
项目摘要
The overall objective of this project is to investigate the role
of natural killer (NK) cells in allogeneic marrow transplantation
with emphasis on their influence on graft rejection, residual
leukemia and leukemia relapse. The goal is to develop a DNA
based typing system ofor the Killer Cell Inhibitory Receptors
(KIR) expressed on NK cells and to investigate how matching
donors and recipients for these receptors will affect the outcome
of marrow transplantation. KIRs are ligands for HLA class I
molecules and some KIRs mediate inhibitory signals for NK cells
while others transduce activating signals. At present, 40
different cDNA clones encoding KIRs have been identified. The
specific aims for the projects are: (i) To determine the exon-
intron organization of genomic KIR genes and develop a genomic
map for the KIR genetic region. (ii) to develop a PCR-DNA based
typing method for KIRs encoded by the individual KIR genes.
(iii) To apply this typing method to a panel of unrelated
individuals and pairs of HLA identical siblings and perform
family segragation analysis for individual KIRs. New KIR genes
will be identified and characterized by neucleotide sequencing of
clones genes. (iv) To develop a gene specific RT-PCR method for
detection of individual KIRs expressed on NK cells. (v) To
determine the IKR genotype in patients and their marrow donors
and determine if patients experiencing graft-rejection, poor
graft function or relapse of leukemia can be distinguished from
patients without these clinical events. (vi) To determine the
pattern of reconstitution of the KIR repertoire as it develops in
themarrow transplant recipient during the post-transplantation
period. This project should determine if matching for KIR
between donors and recipients of allogeneic marrow grafts will
affect the risk for graft rejection and the risk for minimal
residual disease and relapse of leukemia. We will simultaneously
investigate the KIR repertoire development in the post-
transplantation period and determine if this influences
transplant outcome.
这个项目的总体目标是调查这个角色
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Bo Dupont其他文献
Bo Dupont的其他文献
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{{ truncateString('Bo Dupont', 18)}}的其他基金
NK RECEPTOR FUNCTION IN HAEMATOPOIETIC STEM CELL TRANSPLANTATION
造血干细胞移植中的 NK 受体功能
- 批准号:
7318389 - 财政年份:2007
- 资助金额:
$ 24.52万 - 项目类别:
GENETICS OF NK CELL RECEPTORS AND HLA LIGANDS
NK 细胞受体和 HLA 配体的遗传学
- 批准号:
7318394 - 财政年份:2007
- 资助金额:
$ 24.52万 - 项目类别:
NK RECEPTOR FOR HLA CLASS I IN MARROW TRANSPLANTATION
骨髓移植中 HLA I 类的 NK 受体
- 批准号:
6336332 - 财政年份:2000
- 资助金额:
$ 24.52万 - 项目类别:
NK RECEPTOR FOR HLA CLASS I IN MARROW TRANSPLANTATION
骨髓移植中 HLA I 类的 NK 受体
- 批准号:
6102007 - 财政年份:1998
- 资助金额:
$ 24.52万 - 项目类别:
GENETICS OF NK CELL RECEPTORS AND HLA LIGANDS
NK 细胞受体和 HLA 配体的遗传学
- 批准号:
8245885 - 财政年份:1998
- 资助金额:
$ 24.52万 - 项目类别:
NK RECEPTOR FUNCTION IN HAEMATOPOIETIC STEM CELL TRANSPLANTATION
造血干细胞移植中的 NK 受体功能
- 批准号:
8245880 - 财政年份:1998
- 资助金额:
$ 24.52万 - 项目类别:
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