HORMONAL CONTRACEPTION & RISK OF HIV ACQUISITION

荷尔蒙避孕

• 批准号: 6369522
• 负责人: Charles Morrison
• 金额: $ 687.31万
• 依托单位: FAMILY HEALTH INTERNATIONAL
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-09-30 至 2004-09-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6369522
• 关键词: HIV infections; clinical research; communicable disease transmission; disease /disorder proneness /risk; human subject; medroxyprogesterone; oral contraceptives; sexually transmitted diseases; virus virus interaction

Primary objective is to measure the effect of use of combined oral contraceptive (COC) or depomedoxyprogesterone acetate (DMPA) on the acquisition of HIV infection. Secondary objectives are to: determinme if HIV seroconversion rates are modified by the presence or duration of other sexually transmitted diseases differently in users of COCs, DMPA, or no hormones, and examine the effect orf COCs or DMPA on factors which have been shown to influence HIV transmission, such as bacterial vaginosis, herpes simplex or human papillomavirus infection, genital HIV shedding, and viral fitness of non-clade B HIV. This study was established through intraagency agreement in FY 1997; the sole source contract for continuation of this study by NICHD was negotiated in Fy2000, to continue through FY2004.

主要目的是测量使用复方口服避孕药（COC）或醋酸羟孕酮（DMPA）对获得HIV感染的影响。 次要目的是：确定服用COCs、DMPA或不服用激素的人群中，其他性传播疾病的存在或持续时间是否改变了HIV血清转换率，并检查COCs或DMPA对已显示影响HIV传播的因素的影响，如细菌性阴道病、单纯疱疹或人乳头瘤病毒感染、生殖器HIV脱落和非进化枝B HIV的病毒适应性。 本研究于1997财政年度通过机构间协议确立; 2000财政年度谈判了NICHD继续进行本研究的唯一来源合同，该合同将持续到2004财政年度。