HORMONAL CONTRACEPTION & RISK OF HIV ACQUISITION

主要目的是衡量使用复方口服避孕药（COC）或醋酸羟孕酮（DMPA）对获得性HIV感染的影响。次要目标是：确定COCs、DMPA或无激素使用者是否因其他性传播疾病的存在或持续时间不同而改变艾滋病毒血清转化率，并检查COCs或DMPA对已被证明影响艾滋病毒传播的因素的影响，如细菌性阴道病、单纯疱疹或人乳头瘤病毒感染、生殖器艾滋病毒脱落和非进化支B型艾滋病毒的病毒适应度。

Primary objective is to measure the effect of use of combined oral contraceptive (COC) or depomedoxyprogesterone acetate (DMPA) on the acquisition of HIV infection. Secondary objectives are to: determinme if HIV seroconversion rates are modified by the presence or duration of other sexually transmitted diseases differently in users of COCs, DMPA, or no hormones, and examine the effect orf COCs or DMPA on factors which have been shown to influence HIV transmission, such as bacterial vaginosis, herpes simplex or human papillomavirus infection, genital HIV shedding, and viral fitness of non-clade B HIV. This study was established through intraagency agreement in FY 1997; the sole source contract for continuation of this study by NICHD was negotiated in Fy2000, to continue through FY2004.