THERAPY GROUPS TO STUDY T-CELL DEPLETION OF DONOR MARROW

这项合同是一项研究的一部分，T细胞消耗无关 供体骨髓移植 主要目的是 确定急性和慢性疾病的发病率和死亡率的降低 慢性移植物抗宿主病（GvHD）可以在 患者接受来自无关供体的T细胞耗尽的骨髓 白血病复发率不会增加， 移植失败 这项前瞻性随机研究将需要 共560名患者。 研究者将对患者进行随机化 T细胞耗竭或无耗竭。 每个治疗组将 使用他们自己的T细胞耗竭方法。 两个重要 这项研究的组成部分是表征移植的 关于移植物中细胞的数量和类型，以及 监测免疫重建 该项目包括4个治疗 一个医疗协调中心。 本研究预计 持续了七年半

This contract is part of a study of T cell-depletion in unrelated donor bone marrow transplantation. The primary objective is to determine if a reduction in morbidity and mortality from acute and chronic graft versus host disease (GvHD) can be achieved in patients given T cell-depleted marrow from an unrelated donor without a counterbalancing increase in relapse of leukemia and graft failure. This prospective, randomized study will require a total of 560 patients. Study investigators will randomize patients to T cell-depletion or no-depletion. Each therapy group will utilize their own method of T cell-depletion. Two important components of this study are to characterize the transplanted marrow with regard to numbers and types of cells in the graft, and to monitor immune reconstitution. This project includes 4 therapy groups and a medical coordinating center. This study is expected to last seven and one-half years.