COMMUNITY AND COHORT SURVEILLANCE PROGRAM

社区和群体监测计划

• 批准号: 6224394
• 负责人: CHRISTIE Mitchell BALLANTYNE
• 金额: $ 39.19万
• 依托单位: BAYLOR COLLEGE OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 1985
• 资助国家: 美国
• 起止时间: 1985-09-01 至 2007-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6224394
• 关键词: atherosclerosis; behavioral /social science research tag; blood glucose; blood lipid; cardiovascular disorder diagnosis; cardiovascular disorder epidemiology; clinical research; cooperative study; coronary disorder; diabetes mellitus; disease /disorder proneness /risk; genetic susceptibility; hemostasis; high density lipoproteins; human mortality; human subject; hypertension; longitudinal human study; magnetic resonance imaging; myocardial infarction; racial /ethnic difference; smoking; triglycerides

ARIC is a large-scale, long-term program that will measure associations of established and suspected coronary heart disease risk factors (CHD) with both atherosclerosis and new CHD events such as myocardial infarction in men and women from four diverse communities. The project has two components: community surveillance of morbidity and mortality, and repeated examinations of a representative cohort of men and women in each community. The community surveillance involves abstracting hospital records and death certificates and investigating out-of- hospital deaths. The representative cohorts include 4,000 persons from each community. Three of these reflect the ethnic composition of the communities in which they live; one cohort is black. All cohort participants are examined four times (1987-90), and 1990-93, 1993-96, and 1996-99), and contacted annually to update their medical histories. Atherosclerosis is measured by carotid and ultrasonography. Arteriosclerosis is measured using retinal photography. Cerebrovascular disease is assessed using MRI in a sample of black and white participants. Rick factors studied include: blood lipids, lipoprotein cholesterols, and apolipoproteins; plasma hemostatic factors; diabetes and glucose intolerance; blood chemistries and hematology and indicators and infectious and inflammatory disease; DNA markers of these risk factors; sitting, supine and standing blood pressures to track the development of hypertension; anthropometry; fasting blood glucose and insulin level as predictors of diabetes; ECG findings; heart rate variability; cigarette and alcohol use; physical activity level; dietary aspects; and family history. The diverse communities can be compared with respect to CHD incidence and medical care and, through the cohort component, with respect to risk factors and peripheral atherosclerosis. The results will provide a measure of the variation in the distribution and determinants of CHD in the U.S. and, within the limits of ecologic analysis, suggest possible reasons for observed differences. The contractor serves as the Central Lipid Laboratory for the ARIC. Duties include performing lipid measurements, including total cholesterol, high density lipoprotein cholesterol, triglycerides, and glucose on samples from all participants under study by the Field Centers.

ARIC是一项大规模的长期计划，将衡量关联性 已确诊和疑似冠心病危险因素(CHD) 动脉粥样硬化和新的冠心病事件，如心肌梗死 来自四个不同社区的男性和女性都发生了脑梗塞。该项目 有两个组成部分：发病率和死亡率的社区监测， 以及对具有代表性的男性和女性队列的反复检查 在每个社区。社区监督包括抽象 医院记录和死亡证明以及调查期间 医院死亡。代表队列包括来自 每个社区。其中三个反映了 他们所在的社区；一个队列是黑人。 所有队列参与者都接受了四次检查(1987-90年)和1990-93年， 1993-96和1996-99)，并每年联系更新他们的医疗信息 历史。动脉粥样硬化是通过颈动脉和超声检查来测量的。 动脉硬化是用视网膜照相来测量的。脑血管 在黑白样本中使用磁共振成像来评估疾病 参与者。研究的瑞克因素包括：血脂、脂蛋白 胆固醇和载脂蛋白；血浆止血因子；糖尿病 和糖耐量异常；血液化学、血液学和指标 以及传染病和炎症性疾病；这些风险的DNA标记 因素；坐位、仰位和站立的血压跟踪 高血压的发展；人体测量；空腹血糖和 胰岛素水平可作为糖尿病的预测因子；心电图表现；心率 可变性；烟酒使用；体力活动水平；饮食 方面；以及家族史。 就冠心病发病率而言，可以比较不同的社区 和医疗保健，并通过队列组成部分，在风险方面 因素与外周动脉粥样硬化。结果将提供一个 中国冠心病分布及决定因素变异的测量方法 美国和，在生态分析的范围内，建议有可能 观察到差异的原因。 该承包商是ARIC的中央脂质实验室。 职责包括进行血脂测量，包括总量 胆固醇、高密度脂蛋白胆固醇、甘油三酯和 现场研究的所有参与者的样本中的葡萄糖 中锋。