Mechanism of LSA Induced Outside-in Signal Transduction
Mechanism of LSA Induced Outside-in Signal Transduction
批准号:
6334125
负责人:
T. KENT GARTNER
金额:
$24.17万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
2001
资助国家:
美国
项目状态:
已结题
起止时间:
2001-05-01 至 2004-04-30
关键词:
biological signal transduction conformation enzyme inhibitors fibrinogen receptors fluorescence microscopy gene induction /repression gene targeting genetically modified animals human tissue immunofluorescence technique immunoprecipitation integrins laboratory mouse peptides phosphorylation platelet activation platelet aggregation protein kinase protein structure function receptor binding receptor expression western blottings
中文摘要
描述:(研究者摘要)本提案的长期目标
英文摘要
DESCRIPTION: (Investigator's abstract) The long term objective of this proposal
is to elucidate the mechanism of outside-in signal transduction mediated by the
platelet fibrinogen receptor, the integrin alphaIIb/beta3. Elucidation of the
mechanism of outside-signal transduction in human platelets is important basic
research. This research is important not only because of the central role of
platelets in cardiovascular disease but also because insight into the mechanism
of outside-in signal transduction is of central importance to cell biology in
general. Gaining insight into the molecular details of outside-in signal
transduction in platelets may provide a rationale for the design of a
pharmaceutical agent able to control at least some of the platelet behavior
which contributes to development and progression of cardiovascular disease. The
long term objective of this proposal will be accomplished by characterizing the
effects of a unique receptor activating peptide on platelet function. This
receptor activating peptide appears to cause platelet aggregation by binding to
alphaIIb and thereby eliciting a conformation change in the fibrinogen receptor
which initiates a platelet activation signal transduction cascade that
culminates in "irreversible" platelet aggregation. The experiments described in
this proposal are designed to reveal how binding of the receptor activating
peptide to the receptor elicits outside-in signal transduction. Hopefully,
these experiments will reveal the type of intra-receptor subunit or
inter-receptor interactions which initiate the outside-in signal transduction
response in platelets and identify the major components of the signal
transduction pathway used to propagate this outside-in signaling.
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Mechanism of alphallbbeta3-mediated outside-in signaling
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批准号:6897378
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项目类别:
-
资助金额:$20.54万
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财政年份:2005
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负责人:T. KENT GARTNER
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依托单位:
Mechanism of LSA Induced Outside-in Signal Transduction
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批准号:6537653
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项目类别:
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资助金额:$24.17万
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财政年份:2001
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负责人:T. KENT GARTNER
-
依托单位:
Mechanism of LSA Induced Outside-in Signal Transduction
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批准号:6638553
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项目类别:
-
资助金额:$20.69万
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财政年份:2001
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负责人:T. KENT GARTNER
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依托单位:
MECHANISM OF PLATELET ACTIVATION BY THE PEPTIDE LSARLAF
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批准号:2234924
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项目类别:
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资助金额:$9.8万
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财政年份:1996
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负责人:T. KENT GARTNER
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依托单位:
MECHANISM OF PLATELET ACTIVATION BY THE PEPTIDE LSARLAF
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批准号:2234925
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项目类别:
-
资助金额:$2.22万
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财政年份:1996
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负责人:T. KENT GARTNER
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依托单位:
MECHANISM OF PLATELET ACTIVATION BY THE PEPTIDE LSARLAF
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批准号:2613016
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项目类别:
-
资助金额:$9.8万
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财政年份:1996
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负责人:T. KENT GARTNER
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依托单位:
MECHANISM OF PLATELETACTIVATION BY THE PEPTIDE LSARLAF
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批准号:6083799
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项目类别:
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资助金额:$13.95万
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财政年份:1996
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负责人:T. KENT GARTNER
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依托单位:
MECHANISM OF PLATELET ACTIVATION BY THE PEPTIDE LSARLAF
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批准号:1101996
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项目类别:
-
资助金额:$2.4万
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财政年份:1996
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负责人:T. KENT GARTNER
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依托单位:
PEPTIDE MIMICS OF THE FG RECEPTOR LIGAND BINDING SITES
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批准号:3365225
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项目类别:
-
资助金额:$1.08万
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财政年份:1991
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负责人:T. KENT GARTNER
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依托单位:
PEPTIDE MIMICS OF THE FG RECEPTOR LIGAND BINDING SITES
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批准号:3365226
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项目类别:
-
资助金额:$16.34万
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财政年份:1991
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负责人:T. KENT GARTNER
-
依托单位:
PEPTIDE MIMICS OF THE FG RECEPTOR LIGAND BINDING SITES
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批准号:2222683
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项目类别:
-
资助金额:$15.71万
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财政年份:1991
-
负责人:T. KENT GARTNER
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依托单位:
PEPTIDE MIMICS OF THE FG RECEPTOR LIGAND BINDING SITES
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批准号:2222685
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项目类别:
-
资助金额:$1.11万
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财政年份:1991
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负责人:T. KENT GARTNER
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依托单位:
PEPTIDE MIMICS OF THE FG RECEPTOR LIGAND BINDING SITES
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批准号:2222684
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项目类别:
-
资助金额:$16.52万
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财政年份:1991
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负责人:T. KENT GARTNER
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依托单位:
SMALL INSTRUMENT GRANT
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批准号:3525549
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项目类别:
-
资助金额:$0.93万
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财政年份:1990
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负责人:T. KENT GARTNER
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依托单位:
RGDS AND LGGAKQAGDV BINDING SITES ON GPIIB/IIIA
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批准号:3440100
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项目类别:
-
资助金额:$9.99万
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财政年份:1989
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负责人:T. KENT GARTNER
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依托单位:
FUNCTION OF THE PLATELET LECTIN (TSP) IN AGGREGATION
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批准号:3439933
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项目类别:
-
资助金额:$7.15万
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财政年份:1985
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负责人:T. KENT GARTNER
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依托单位:
海外基金