COMPARATIVE ANALYSIS OF METABOLIC RESPONSE TO ACTH STIMULATION

ACTH 刺激代谢反应的比较分析

• 批准号: 6263845
• 负责人: JUDSON J VAN-WYK
• 金额: $ 0.02万
• 依托单位: UNIV OF NORTH CAROLINA CHAPEL HILL
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-12-01 至 1999-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6263845
• 关键词: adrenalectomy; adrenocorticotropic hormone; child (0-11); clinical research; congenital adrenal hyperplasia; hormone regulation /control mechanism; human subject; metabolism

The purpose of this study is to evaluate the metabolic response to ACTH stimulation in children with congenital adrenal hyperplasia before and after pro-phylactic adrenalectomy, and compare it to normal controls. One possible objection raised to adrenalectomy in these patients has been that the loss of all adrenal tissue may leave them at a greater risk for adrenal crisis in times of stress.

本研究的目的是评估先天性肾上腺增生症患儿预防性肾上腺切除术前后对促肾上腺皮质激素刺激的代谢反应，并与正常对照组进行比较。 对这些患者肾上腺切除术的一个可能的反对意见是，所有肾上腺组织的损失可能使他们在压力下发生肾上腺危象的风险更大。