BRL49653C-- STUDY OF ABSORPTIVE, POST ABS SLELETAL MUSCLE/HEPATIC METABOLISM

BRL49653C-- 吸收、腹肌后骨骼肌/肝脏代谢的研究

• 批准号: 6113770
• 负责人: JOHN E GERICH
• 金额: $ 1.48万
• 依托单位: UNIVERSITY OF ROCHESTER
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-12-01 至 1999-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6113770
• 关键词: clinical research; diabetes mellitus therapy; fasting; glucose metabolism; human subject; human therapy evaluation; hypoglycemic agents; liver metabolism; muscle metabolism; noninsulin dependent diabetes mellitus; pharmacokinetics; striated muscles; thiazoles

This study is a double-blind randomized placebo-controlled group study in which patients with non-insulin dependent diabetes mellitus will be treated with a new agent (BRL 49653) which is thought to act to improve insulin sensitivity. The specific aim of the study are to determine whether fasting and post-prandial hyperglycemia is improved by restoring hepatic glucose metabolism to normal and to determine whether the post-prandial plasma lipid profile is improved.

本研究是一项双盲、随机、安慰剂对照组研究，其中非胰岛素依赖型糖尿病患者将接受一种被认为可改善胰岛素敏感性的新药（BRL 49653）治疗。 本研究的具体目的是确定是否通过将肝脏葡萄糖代谢恢复至正常来改善空腹和餐后高血糖症，并确定餐后血脂谱是否得到改善。