ROLE OF THE KIDNEY IN GLUCOSE HOMEOSTASIS IN NORMAL AND DIABETIC HUMANS

肾脏在正常人和糖尿病人葡萄糖稳态中的作用

• 批准号: 6303835
• 负责人: JOHN E GERICH
• 金额: $ 1.48万
• 依托单位: UNIVERSITY OF ROCHESTER
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-12-01 至 2001-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6303835
• 关键词: clinical research; glucose metabolism; human subject; kidney; kidney function; noninsulin dependent diabetes mellitus

To test the hypothesis that there is excessive renal glucose production in people with type 2 diabetes mellitus and to test the hypothesis that insulin suppresses RGP in normal humans and that this suppression is impaired in NIDDM. To test the hypothesis that the human kidney contributes to the compensatory increase in appearance of glucose in plasma during hypoglycemia and this is impaired in NIDDM.

检验2型糖尿病患者肾脏葡萄糖产生过多的假说，以及胰岛素抑制正常人RGP的假说以及NIDDM患者这种抑制作用受损的假说。为了验证这一假设，即人类肾脏有助于在低血糖期间血浆中葡萄糖的代偿性增加，而这在NIDDM中是受损的。