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HIVIG PREVENTION OF MATERNAL/FETAL HIV TRANSMISION IN PREGNANT WOMEN

HIVIG PREVENTION OF MATERNAL/FETAL HIV TRANSMISION IN PREGNANT WOMEN
HIVIG 预防孕妇母体/胎儿 HIV 传播
批准号：
6116753
负责人：
William Thomas Shearer
金额：
$3.6万
依托单位：
BAYLOR COLLEGE OF MEDICINE
依托单位国家：
美国
项目类别：
财政年份：
1998
资助国家：
美国
项目状态：
已结题
起止时间：
1998-12-01 至 1999-11-30
来源：
https://reporter.nih.gov/project-details/6116753
关键词：
AIDS therapy HIV infections antiviral antibody chemoprevention clinical research combination therapy communicable disease transmission drug screening /evaluation human pregnant subject human subject human therapy evaluation immunoglobulins immunotherapy intravenous administration newborn human (0-6 weeks) placental transfer pregnancy infection vertical transmission zidovudine

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中文摘要
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英文摘要
This study hypothesizes that hyperimmune anti-HIV intravenous immunoglobulin (HIVIG) will be efficacious, safe, and tolerable when administered with ZDV to HIV-infected pregnant women and their newborn infants for prevention of vertical transmission of HIV. This study was stopped by the Data, Safety, and Monitoring Board because of lack of efficacy using the currently projected number of patients and because of slow accrual. One important finding was that both treatment and control patients had a vertical HIV transmission rate of less than 5%, an improvement over previous research data.
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