Clinical Research Core

Baylor-UTHouston CFAR临床研究核心一直采取积极主动的方法来促进跨学科的艾滋病毒/艾滋病转化研究，该研究已经产生了超过70篇Baylor-UTHouston CFAR研究人员的同行评审出版物以及许多摘要介绍和出版物。联合主任是William T. Shearer（儿科部分）和Roberto C. Arduino（成人组件）。核心的目标是：（1）提供综合访问儿童和成人患者艾滋病毒感染人群和临床资料;（2）促进新的研究，有针对性的研究项目，并在艾滋病毒/艾滋病研究的关键领域的科学计划;（3）建立社区外展和教育计划，以扩大CFAR研究的机会;和（4）协助研究人员解释艾滋病毒研究数据。充分表征的患者人群和临床材料的来源是德克萨斯州儿童医院的儿科HIV研究中心和托马斯街健康中心（贝勒和UTHOUSTON）的休斯顿艾滋病研究小组站点，那里可以看到成年患者。超过100名儿童和3000名成人被跟踪; NIH资助的HIV研究项目支持对这些患者的临床研究（IMPAACT，PHACS，INSIGHT和ACTG）。退伍军人事务医疗中心是感染艾滋病毒的成人的另一个来源（700多名患者）。核心服务包括提供有关患者人群的信息和协助采购标本。一个核心监督委员会负责审查和优先处理获取患者或样本的请求（概念表）。核心收集、处理和存储患者研究材料，用于批准的研究。核心将协助调查人员进入PHACS 国家数据库及其中央标本库。在本地，从选定的成年病人的标本被储存起来用于研究。该核心提供了至关重要的支持，以新的努力，目标转化研究领域的差距，在我们的CFAR，并鼓励CFAR核心和CFAR成员之间的互动在贝勒和UTHOUSTON。最近的几个例子中，核心促进创新的合作研究。核心与社区团体合作，赞助临床会议，并传播信息，以促进CFAR研究的机会。每年将使用成果衡量标准来评估核心方案的成功。

The Baylor-UTHouston CFAR Clinical Research Core has maintained a proactive approach to facilitating interdisciplinary HIV/AIDS translational research that has produced over 70 peer-reviewed publications of Baylor-UTHouston CFAR investigators as well as numerous abstract presentations and publications. The Co-Directors are Dr. William T. Shearer (Pediatric Component) and Dr. Roberto C. Arduino (Adult Component). The goals of the Core are to: (1) Provide integrated access to pediatric and adult patient HIV-infected populations and clinical materials; (2) Facilitate novel research, targeted research projects, and scientific programs in critical areas of HIV/AIDS research; (3) Establish community outreach and educational programs to expand CFAR research opportunities; and (4) Assist investigators with interpretation of HIV study data. The sources of well-characterized patient populations and clinical materials are the Pediatric HIV Research Center at Texas Children's Hospital and the Houston AIDS Research Team site at Thomas Street Health Center (Baylor and UTHouston) where adult patients are seen. More than 100 children and 3000 adults are followed; NIH-funded HIV research programs support clinical studies on these patients (IMPAACT, PHACS, INSIGHT and ACTG). The Veterans Affairs Medical Center is another source of HIV-infected adults (over 700 patients). Core services include providing information on patient populations and assisting with procurement of specimens. A Core Oversight Committee reviews and prioritizes requests (concept sheets) for access to patients or specimens. The Core collects, processes, and stores patient research materials for approved studies. The Core will assist investigators in gaining access to the PHACS national database and its centralized specimen repository. Locally, specimens from selected adult patients are banked for research studies. The Core provides crucial support to new efforts to target translational research into areas that are gaps at our CFAR and that encourage interactions among CFAR cores and CFAR members at Baylor and UTHouston. Several recent examples are described in which the Core fostered innovative collaborative studies. The Core works with community groups, sponsors clinical conferences, and disseminates information to promote CFAR research opportunities. Outcomes measures will be used to assess the success of the Core each year.