Clinical Research Core

贝勒-休斯敦大学CFAR临床研究核心一直保持积极主动的态度，促进跨学科的艾滋病毒/艾滋病转化研究，已经出版了70多份贝勒-UT休斯顿CFAR研究人员的同行评议出版物以及许多摘要报告和出版物。联合主任是威廉·T·希勒博士(儿科)和罗伯托·C·阿杜伊诺博士(成人部分)。该中心的目标是：(1)为儿童和成人感染艾滋病毒的人群和临床材料提供综合途径；(2)促进艾滋病毒/艾滋病研究关键领域的新研究、有针对性的研究项目和科学计划；(3)建立社区推广和教育计划，以扩大CFAR的研究机会；以及(4)协助调查人员解释艾滋病毒研究数据。有特色的患者群体和临床材料的来源是德克萨斯州儿童医院的儿科艾滋病毒研究中心和托马斯街道健康中心(贝勒和休斯顿大学)的休斯顿艾滋病研究小组网站，那里有成人患者。对100多名儿童和3000名成年人进行了跟踪调查；NIH资助的艾滋病毒研究项目支持对这些患者的临床研究(IMPAACT、PHACS、Insight和ACTG)。退伍军人事务医疗中心是感染艾滋病毒的成年人(超过700名患者)的另一个来源。核心服务包括提供有关患者群体的信息和协助购买标本。核心监督委员会审查并确定接触患者或标本的请求(概念表)的优先顺序。该中心收集、处理和存储患者研究材料，以供批准的研究使用。核心将协助调查人员进入PHACS 国家数据库及其中央标本储存库。在当地，来自选定的成年患者的样本被储存起来进行研究。核心为针对我们CFAR空白领域的翻译研究的新努力提供关键支持，这些领域鼓励贝勒和休斯顿的CFAR核心和CFAR成员之间的互动。文中描述了核心促进创新合作研究的几个最新实例。CORE与社区团体合作，赞助临床会议，传播信息以促进CFAR的研究机会。每年将使用成果衡量标准来评估核心项目的成功。

The Baylor-UTHouston CFAR Clinical Research Core has maintained a proactive approach to facilitating interdisciplinary HIV/AIDS translational research that has produced over 70 peer-reviewed publications of Baylor-UTHouston CFAR investigators as well as numerous abstract presentations and publications. The Co-Directors are Dr. William T. Shearer (Pediatric Component) and Dr. Roberto C. Arduino (Adult Component). The goals of the Core are to: (1) Provide integrated access to pediatric and adult patient HIV-infected populations and clinical materials; (2) Facilitate novel research, targeted research projects, and scientific programs in critical areas of HIV/AIDS research; (3) Establish community outreach and educational programs to expand CFAR research opportunities; and (4) Assist investigators with interpretation of HIV study data. The sources of well-characterized patient populations and clinical materials are the Pediatric HIV Research Center at Texas Children's Hospital and the Houston AIDS Research Team site at Thomas Street Health Center (Baylor and UTHouston) where adult patients are seen. More than 100 children and 3000 adults are followed; NIH-funded HIV research programs support clinical studies on these patients (IMPAACT, PHACS, INSIGHT and ACTG). The Veterans Affairs Medical Center is another source of HIV-infected adults (over 700 patients). Core services include providing information on patient populations and assisting with procurement of specimens. A Core Oversight Committee reviews and prioritizes requests (concept sheets) for access to patients or specimens. The Core collects, processes, and stores patient research materials for approved studies. The Core will assist investigators in gaining access to the PHACS national database and its centralized specimen repository. Locally, specimens from selected adult patients are banked for research studies. The Core provides crucial support to new efforts to target translational research into areas that are gaps at our CFAR and that encourage interactions among CFAR cores and CFAR members at Baylor and UTHouston. Several recent examples are described in which the Core fostered innovative collaborative studies. The Core works with community groups, sponsors clinical conferences, and disseminates information to promote CFAR research opportunities. Outcomes measures will be used to assess the success of the Core each year.