Clinical Research Core

贝勒-休斯顿CFAR临床研究核心一直保持积极主动的方法，促进跨学科的艾滋病毒/艾滋病转化研究，已经产生了70多篇贝勒-休斯顿CFAR研究人员的同行评审出版物，以及大量的摘要报告和出版物。联合董事是William T. Shearer博士（儿科部分）和Roberto C. Arduino博士（成人部分）。核心的目标是：(1)向感染艾滋病毒的儿童和成人患者提供综合服务，并提供临床材料；(2)促进艾滋病毒/艾滋病研究关键领域的新研究、有针对性的研究项目和科学计划；(3)建立社区外展和教育项目，扩大CFAR研究机会；(4)协助研究者解读HIV研究数据。有明确特征的患者群体和临床资料的来源是德克萨斯儿童医院的儿科艾滋病研究中心和托马斯街健康中心（贝勒和休斯顿）的休斯顿艾滋病研究小组，在那里可以看到成年患者。研究跟踪了100多名儿童和3000名成年人；美国国立卫生研究院资助的艾滋病研究项目支持对这些患者进行临床研究（IMPAACT、PHACS、INSIGHT和ACTG）。退伍军人事务医疗中心是感染艾滋病毒的成年人的另一个来源（超过700名患者）。核心服务包括提供患者群体信息和协助获取标本。核心监督委员会审查并确定获取患者或标本的请求（概念表）的优先顺序。该中心收集、处理和储存经批准研究的患者研究材料。核心将协助调查人员进入PHACS

The Baylor-UTHouston CFAR Clinical Research Core has maintained a proactive approach to facilitating interdisciplinary HIV/AIDS translational research that has produced over 70 peer-reviewed publications of Baylor-UTHouston CFAR investigators as well as numerous abstract presentations and publications. The Co-Directors are Dr. William T. Shearer (Pediatric Component) and Dr. Roberto C. Arduino (Adult Component). The goals of the Core are to: (1) Provide integrated access to pediatric and adult patient HIV-infected populations and clinical materials; (2) Facilitate novel research, targeted research projects, and scientific programs in critical areas of HIV/AIDS research; (3) Establish community outreach and educational programs to expand CFAR research opportunities; and (4) Assist investigators with interpretation of HIV study data. The sources of well-characterized patient populations and clinical materials are the Pediatric HIV Research Center at Texas Children's Hospital and the Houston AIDS Research Team site at Thomas Street Health Center (Baylor and UTHouston) where adult patients are seen. More than 100 children and 3000 adults are followed; NIH-funded HIV research programs support clinical studies on these patients (IMPAACT, PHACS, INSIGHT and ACTG). The Veterans Affairs Medical Center is another source of HIV-infected adults (over 700 patients). Core services include providing information on patient populations and assisting with procurement of specimens. A Core Oversight Committee reviews and prioritizes requests (concept sheets) for access to patients or specimens. The Core collects, processes, and stores patient research materials for approved studies. The Core will assist investigators in gaining access to the PHACS national database and its centralized specimen repository. Locally, specimens from selected adult patients are banked for research studies. The Core provides crucial support to new efforts to target translational research into areas that are gaps at our CFAR and that encourage interactions among CFAR cores and CFAR members at Baylor and UTHouston. Several recent examples are described in which the Core fostered innovative collaborative studies. The Core works with community groups, sponsors clinical conferences, and disseminates information to promote CFAR research opportunities. Outcomes measures will be used to assess the success of the Core each year.