MUTATIONS IN THE HPRT GENE, SMOKING AND LUNG CANCER

HPRT 基因突变、吸烟与肺癌

• 批准号: 6115951
• 负责人: MARC S GREENBLATT
• 金额: $ 3.29万
• 依托单位: UNIVERSITY OF VERMONT & ST AGRIC COLLEGE
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-12-01 至 1999-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6115951
• 关键词: carcinogenesis; clinical research; gene mutation; genetic markers; human subject; hypoxanthine phosphoribosyltransferase; lung neoplasms; respiratory epithelium; smoking

Carcinogen-induced mutations to cancer-related genes in target tissues such as bronchial epithelium are thought to be a major mechanism of carcinogenesis. Since detection of mutations in most genes in target tissues is not practical,a surrogate gene which could indicate critical somatic mutations would provide insight into cancer-related mutagenesis. The hypoxanthine phosphoribosyl transferase gene is a good surrogate gene for study,since HPRT mutants are a selectable phenotype which represent a marker for generalized somatic mutation.

致癌物诱导靶组织中癌症相关基因的突变