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SAFETY, EFFICACY, AND CELLULAR MECHANISMS OF 6 THIOGUANINE IN PSORIASIS

SAFETY, EFFICACY, AND CELLULAR MECHANISMS OF 6 THIOGUANINE IN PSORIASIS
6 硫鸟嘌呤治疗银屑病的安全性、有效性和细胞机制
批准号：
6115857
负责人：
JAMES G KRUEGER
金额：
$4.54万
依托单位：
ROCKEFELLER UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
1997
资助国家：
美国
项目状态：
已结题
起止时间：
1997-12-01 至 1999-11-30
来源：
https://reporter.nih.gov/project-details/6115857
关键词：
6 thioguanine clinical chemistry clinical research drug screening /evaluation human subject psoriasis skin disorder chemotherapy tissue /cell culture

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英文摘要
We are studying the mechanism of the cytotoxic agent, 6-thioguanine, on psoriasis and are doing this through blood kinetic studies and direct skin tissue studies. 6-thioguanine is a guanine analog which is incorporated into the DNA in the cell in place of the normal guanine component. This prevents the cell from replicating. Incorporation of this agent is much greater in young, rapidly growing cell populations than in older populations. The use of this drug in psoriasis makes sense, as psoriasis is a disease of rapidly proliferating keratinocytes, as well as proliferating lymphocytes with skin lesions.
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PHARMACODYNAMIC EFFECTS OF CYCLOSPORINE A IN MODERATE-SEVERE PSORIASIS
  • 批准号：
    7206998
  • 项目类别：
  • 资助金额：
    $0.03万
  • 财政年份：
    2005
  • 负责人：
    JAMES G KRUEGER
  • 依托单位：
    ROCKEFELLER UNIVERSITY
SKIN BIOPSY FOR ANALYSIS OF CELL GROWTH, CELL DIFFERENTIATION AND INFLAMMATION
  • 批准号：
    7207013
  • 项目类别：
  • 资助金额：
    $0.03万
  • 财政年份：
    2005
  • 负责人：
    JAMES G KRUEGER
  • 依托单位：
    ROCKEFELLER UNIVERSITY
NATURAL COURSE & HISTORY OF PSORIASIS BEFORE, DURING AND AFTER TREATMENT
  • 批准号：
    7207001
  • 项目类别：
  • 资助金额：
    $21.79万
  • 财政年份：
    2005
  • 负责人：
    JAMES G KRUEGER
  • 依托单位：
    ROCKEFELLER UNIVERSITY
COLLECTION OF BLOOD SPECIMENS FOR RESEARCH PURPOSES
  • 批准号：
    7206995
  • 项目类别：
  • 资助金额：
    $2.94万
  • 财政年份：
    2005
  • 负责人：
    JAMES G KRUEGER
  • 依托单位：
    ROCKEFELLER UNIVERSITY
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