NEUTROPHIL ACTIVATION IN ACUTE HUMAN CENTRAL NERVOUS SYSTEM INJURY

中性粒细胞激活加剧脑损伤的假说 急性中风目前得到了广泛的接受。然而， 中性粒细胞激活与脑缺血事件的时间关系 临床状态尚不清楚。因此，这项研究是为了 鲁米诺依赖技术检测人中性粒细胞活化 急性迟缓和出血性卒中的化学发光。病人 (平淡，n-18；出血性，n=16)在6个月内进入本研究 《伊卡特斯》的时间。这些结果与其他临床中心进行了比较 神经系统损害：蛛网膜下腔出血(n=11)，脊柱损伤 单纯闭合性头痛伤19例。所有受试者都进行了抽样 在出现在急诊室时以及0.5、1、2、3、4和5天 在这件事之后。中性粒细胞激活，由鲁米诺- 依赖的化学发光，在发病后第1天明显 轻度卒中组(p&lt；0.05)，尽管这一趋势没有表现出来 治疗出血性中风。闭合性头部损伤患者 显示出较高的中性粒细胞初始激活程度，数值为 在第0.5天(p-9.91)和第1天(p=0.05)显著低于基线。不是 在有脊柱创伤或 蛛网膜下腔出血。这些结果支持中性粒细胞的作用 在各种中枢神经系统侮辱期间激活，并提供 考虑针对暂时性药物治疗的时间框架 抑制中性粒细胞功能。

The hypothesis that neutrophil activation exacerbates brain injury in acute stroke is currently receiving wide acceptance. However, the temporal relationship of neutrophil activation to the ischemic event in clinical states is not clear. Therefore, this study was undertaken to examine human neutrophil activation by the technique of luminol-dependent chemiluminescence in both acute bland and hemorrhagic stroke. Patients (bland, n-18; hemorrhagic, n=16) were entered into this study within six hours of the ictus. These results were compared to other clinical central nervous system insults: subarachnoid hemorrhage (n=11), spinal trauma (n=9) and isolated closed heady injury (n=19). All subjects were sampled upon presentation to the emergency room and 0.5, 1, 2, 3, 4 and 5 days following the event. Neutrophil activation, as determined by luminol- dependent chemiluminescence, was evident at day 1 following the ictus in the bland stroke group (p<0.05), although this trend was not demonstrated for hemorrhagic stroke. Patients suffering a closed head injury demonstrated greater initial neutrophil activation with values being significantly lower than baseline at days 0.5 (p-9.91) and 1 (p=0.05). No significant change was demonstrated for the groups with spinal trauma or subarachnoid hemorrhage. These results support a role for neutrophil activation during various central nervous system insults and provide a temporal framework for considering drug therapy directed at transient suppression of neutrophil function.