CHILD DEVELOPMENT IN RELATION TO EARLY OTITIS MEDIA

与早期中耳炎相关的儿童发育

• 批准号: 6115541
• 负责人: JACK L PARADISE
• 金额: $ 2.06万
• 依托单位: CHILDREN'S HOSP PITTSBURGH/UPMC HLTH SYS
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-12-01 至 1999-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6115541
• 关键词: child (0-11); child mental disorders; child psychology; clinical research; disease /disorder proneness /risk; ear surgery; exudate /transudate; human subject; human therapy evaluation; language development; mental disorder prevention; otitis media

The main objectives are to determine whether persistent otitis media with effusion (ome) in the first 3 years of life results in lasting impairments of speech, language, cognitive, or psychosocial development, and if so, whether they are prevented or lessened by prompt tympanostomy-tube placement (TTP). From 2 hospitals and 6 pediatric practices 6391 well infants aged <2mo were enrolled. Middle-ear status and hearing are monitored. Up to age 3, children who reach specified criteria regarding persistent OME are randomized to undergo TTP either promptly or after a defined extended period of OME persists. Detailed developmental tests are administered at ages 3, 4 and 6 yr to all subjects who had met randomization criteria and to a sample of others representing a spectrum of OME experience. Analyses of results will enable determinations whether associations exist between early OME and later developmental impairments; if so, whether the associations are causal; and whether prompt TTP is effective in preventing or lessening such impairments.

主要目的是确定在出生后3年内持续性渗出性中耳炎（ome）是否会导致言语、语言、认知或心理社会发育的持久性损害，如果是，是否可以通过及时放置鼓室造口管（TTP）来预防或减轻。 从2家医院和6个儿科诊所招募了6391名<2个月的健康婴儿。 监测中耳状况和听力。 在3岁以下，达到关于持续性OME的特定标准的儿童随机接受TTP，要么立即接受TTP，要么在OME持续一段规定的延长期后接受TTP。 在3岁、4岁和6岁时，对所有符合随机化标准的受试者和代表OME经历谱的其他受试者进行详细的发育测试。 结果分析将能够确定早期OME和后来的发育障碍之间是否存在关联;如果是，这些关联是否是因果关系;以及及时TTP是否能有效预防或减轻此类障碍。