CHILD DEVELOPMENT IN RELATION TO EARLY OTITIS MEDIA

主要目的是确定3岁前持续性中耳炎伴积液（部分）是否会导致言语、语言、认知或社会心理发育的持续损害，如果是，是否可以通过鼓膜造瘘管置入术（TTP）预防或减轻这些损害。来自2家医院和6家儿科诊所的6391名年龄<2个月的健康婴儿入组。监测中耳状态和听力。在3岁以下，达到持久性OME特定标准的儿童随机接受TTP治疗，要么立即接受TTP治疗，要么在OME持续一段时间后接受TTP治疗。在3岁、4岁和6岁时，对所有符合随机标准的受试者和代表OME经历谱的其他受试者进行详细的发育测试。分析结果将有助于确定早期OME与后期发育障碍之间是否存在关联；如果有，这些关联是否具有因果关系；以及快速TTP是否有效预防或减轻此类损伤。

The main objectives are to determine whether persistent otitis media with effusion (ome) in the first 3 years of life results in lasting impairments of speech, language, cognitive, or psychosocial development, and if so, whether they are prevented or lessened by prompt tympanostomy-tube placement (TTP). From 2 hospitals and 6 pediatric practices 6391 well infants aged <2mo were enrolled. Middle-ear status and hearing are monitored. Up to age 3, children who reach specified criteria regarding persistent OME are randomized to undergo TTP either promptly or after a defined extended period of OME persists. Detailed developmental tests are administered at ages 3, 4 and 6 yr to all subjects who had met randomization criteria and to a sample of others representing a spectrum of OME experience. Analyses of results will enable determinations whether associations exist between early OME and later developmental impairments; if so, whether the associations are causal; and whether prompt TTP is effective in preventing or lessening such impairments.