CHILD DEVELOPMENT IN RELATION TO EARLY OTITIS MEDIA

与早期中耳炎相关的儿童发育

• 批准号: 6276775
• 负责人: JACK L PARADISE
• 金额: $ 1.51万
• 依托单位: CHILDREN'S HOSP PITTSBURGH/UPMC HLTH SYS
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-12-01 至 1998-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6276775
• 关键词: child (0-11); child mental disorders; child psychology; clinical research; disease /disorder proneness /risk; ear surgery; exudate /transudate; human subject; human therapy evaluation; language development; mental disorder prevention; otitis media

This study's main objectives are to determine whether persistent otitis media with effusion (OME) in the first 3 years of life results in lasting impairments of speech, language, cognitive, or psychosocial development, and if so, whether they are prevented or lessened by prompt tympanostomy- tube placement (TTP). From 2 hospitals and 6 pediatric practices 6391 well infants aged <2mo were enrolled. Middle-ear status and hearing are monitored. Up to age 3, children who reach specified criteria regarding persistent OME are randomized to undergo TTP either promptly or after a defined extended period of OME persists. Detailed developmental tests are administered at ages 3, 4 and 6 yr to all subjects who had met randomization criteria and to a sample of others representing a spectrum of OME experience. Analyses of results will enable determinations whether associations exist between early OME and later developmental impairments; if so, whether the associations are causal; and whether prompt TTP is effective in preventing or lessening such impairments.

本研究的主要目的是确定持续性中耳炎是否 中膜积液（OME）在生命的前3年导致持续 言语、语言、认知或心理社会发展障碍， 如果是这样的话，是否可以通过及时的鼓膜造口术来预防或减轻这些疾病， 管放置（TTP）。 来自2家医院和6家儿科诊所6391 入选年龄<2个月的健康婴儿。 中耳状况和听力 监测。 3岁以下的儿童，如果在以下方面达到特定标准， 持续性OME随机接受TTP，无论是立即或之后， OME的定义延长期持续存在。 详细的开发测试是 在3岁、4岁和6岁时，对所有符合以下条件的受试者进行给药： 随机化标准和代表频谱的其他样本 OME的经验。 对结果的分析将有助于确定 早期OME和后期发育障碍之间存在关联; 若有，两者之间是否有因果关系，以及即时TTP是否 有效地防止或减轻这种损害。