MECHANISMS GOVERNING HYPERACUTE REJECTION OF THE LUNG
MECHANISMS GOVERNING HYPERACUTE REJECTION OF THE LUNG
批准号:
6115590
负责人:
Richard N Pierson
金额:
$3.64万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
1998
资助国家:
美国
项目状态:
已结题
起止时间:
1998-12-01 至 1999-11-30
中文摘要
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英文摘要
An ex vivo model using human blood to perfuse pig lungs is used to study
the hyperacute rejection response. Two separate components to this
response have been identified, vasoconstriction and capillary leak.
Using blockers of thromboxane synthesis we are able to attenuate the
vasoconstriction; strategies which inhibit complement mediated injury
appear to block much of the capillary leak syndrome. Transgenic
strategies are being developed to address these components separately and
in conjunction.
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会议论文
Project 3: Enhanced Costimulation Blockade to Achieve Clinically Relevant Heart Allograft Tolerance
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批准号:10457402
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项目类别:
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资助金额:$66.53万
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财政年份:2021
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负责人:Richard N Pierson
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依托单位:
Project 3: Enhanced Costimulation Blockade to Achieve Clinically Relevant Heart Allograft Tolerance
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批准号:10270362
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项目类别:
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资助金额:$66.53万
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财政年份:2021
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负责人:Richard N Pierson
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依托单位:
Project 3: Enhanced Costimulation Blockade to Achieve Clinically Relevant Heart Allograft Tolerance
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批准号:10673082
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项目类别:
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资助金额:$66.53万
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财政年份:2021
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负责人:Richard N Pierson
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依托单位:
CRISPR-Modified Cardiac Xenograft Transplantation
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批准号:10033905
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项目类别:
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资助金额:$79.57万
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财政年份:2020
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负责人:Richard N Pierson
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依托单位:
CRISPR-Modified Cardiac Xenograft Transplantation
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批准号:10188418
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项目类别:
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资助金额:$79.57万
-
财政年份:2020
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负责人:Richard N Pierson
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依托单位:
CRISPR-Modified Cardiac Xenograft Transplantation
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批准号:10403525
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项目类别:
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资助金额:$79.57万
-
财政年份:2020
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负责人:Richard N Pierson
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依托单位:
CRISPR-Modified Cardiac Xenograft Transplantation
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批准号:10632137
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项目类别:
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资助金额:$79.57万
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财政年份:2020
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负责人:Richard N Pierson
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依托单位:
Coagulation Control To Protect Gaitko Lung and Liver Xenografts
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批准号:8009659
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项目类别:
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资助金额:$72.68万
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财政年份:2010
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负责人:Richard N Pierson
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依托单位:
Immunomodulation for Heart Allograft Tolerance
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批准号:7918484
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项目类别:
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资助金额:$41.0万
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财政年份:2009
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负责人:Richard N Pierson
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依托单位:
Mechanisms of GalTKO Lung Xenograft Injury
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批准号:7901325
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项目类别:
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资助金额:$34.0万
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财政年份:2009
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负责人:Richard N Pierson
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依托单位:
Immunomodulation for Heart Allograft Tolerance
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批准号:7002147
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项目类别:
-
资助金额:$62.14万
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财政年份:2005
-
负责人:Richard N Pierson
-
依托单位:
Immunomodulation for Heart Allograft Tolerance
-
批准号:7449614
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项目类别:
-
资助金额:$68.88万
-
财政年份:2005
-
负责人:Richard N Pierson
-
依托单位:
Mechanisms of GalTKO Lung Xenograft Injury
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批准号:7217329
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项目类别:
-
资助金额:$44.5万
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财政年份:2005
-
负责人:Richard N Pierson
-
依托单位:
Immunomodulation for Heart Allograft Tolerance
-
批准号:8492009
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项目类别:
-
资助金额:$67.06万
-
财政年份:2005
-
负责人:Richard N Pierson
-
依托单位:
Immunomodulation for Heart Allograft Tolerance
-
批准号:8292196
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项目类别:
-
资助金额:$68.43万
-
财政年份:2005
-
负责人:Richard N Pierson
-
依托单位:
Immunomodulation for Heart Allograft Tolerance
-
批准号:8009669
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项目类别:
-
资助金额:$69.14万
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财政年份:2005
-
负责人:Richard N Pierson
-
依托单位:
Mechanisms of GalTKO Lung Xenograft Injury
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批准号:7124733
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项目类别:
-
资助金额:$44.74万
-
财政年份:2005
-
负责人:Richard N Pierson
-
依托单位:
Immunomodulation for Heart Allograft Tolerance
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批准号:7268919
-
项目类别:
-
资助金额:$68.26万
-
财政年份:2005
-
负责人:Richard N Pierson
-
依托单位:
Immunomodulation for Heart Allograft Tolerance
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批准号:8683071
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项目类别:
-
资助金额:$70.52万
-
财政年份:2005
-
负责人:Richard N Pierson
-
依托单位:
Immunomodulation for Heart Allograft Tolerance
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批准号:7657466
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项目类别:
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资助金额:$70.85万
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财政年份:2005
-
负责人:Richard N Pierson
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依托单位:
海外基金